Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins
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概要
- 論文の詳細を見る
In dog pulmonary arterial and venous strips without endothelium under treatment with prazosin, nicotine induced relaxation that was abolished by NG-nitro-<sc>L</sc>-arginine, hexamethonium and methylene blue. <sc>L</sc>-Arginine antagonized the NG-nitro-<sc>L</sc>-arginine action. Neurogenic relaxations tended to be more evident in the vein. Nitric oxide (NO)-induced relaxations were greater in the veins than in the arteries. Concentrations of NO to induce the same magnitude of relaxation as that to nicotine were higher in the arteries. In conclusion, dog pulmonary arteries and veins are innervated by nitroxidergic (nitrergic) nerves, and NO is released by nerve stimulation with nicotine in a larger amount in the artery than the vein.
- 社団法人 日本薬理学会の論文
- 2002-06-01
著者
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Toda Noboru
Department of Pharmacology, Sniga University of Medical Sciences
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OKAMURA Tomio
Department of Pharmacology, Shiga University of Medical Science
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Okamura T
Department Of Pharmacology Shiga University Of Medical Science
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AYAJIKI Kazuhide
Department of Pharmacology, Shiga University of Medical Science
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Okamura Tomio
Department Of Pharmacology
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Toda N
Department Of Pharmacology Shiga University Of Medical Science
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Okamura T
Shiga Univ. Medical Sci. Ohtsu Jpn
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Toda Noboru
Department Of Pharmacology Shiga University Of Medical Science
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NODA Kumiko
Research Laboratories, Nippon Shinyaku Co., Ltd.
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Noda Kumiko
Research Laboratories Nippon Shinyaku Co.
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Ayajiki Kazuhide
Department Of Pharmacology Shiga University Of Medical Science
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Ayajiki Kazuhide
Department Of Pharmacy School Of Pharmacy Hyogo University Of Health Sciences
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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