SEROTONIN ANTAGONISM IN ISOLATED CANINE CEREBRAL ARTERIES
スポンサーリンク
概要
- 論文の詳細を見る
In helically-cut strips of canine cerebral arteries, the dose-response curve of serotonin was not influenced by 10<SUP>-7</SUP> M phentolamine but was slightly moved to the right and downward at 10<SUP>-6</SUP> M. The contractile response to serotonin was unaffected by cocaine (3×10<SUP>-6</SUP> M), atropine (10<SUP>-6</SUP> M) and propranolol (10<SUP>-6</SUP> M). The addition of lysergic acid diethylamide (LSD), ergotamine and methysergide caused a dose-dependent contraction. Treatment with LSD (10<SUP>-9</SUP> and 10<SUP>-8</SUP> M), ergotamine (10<SUP>-10</SUP> to 10<SUP>-8</SUP> M) and methysergide (10<SUP>-8</SUP> to 10<SUP>-6</SUP> M) shifted the dose-response curve of serotonin to the right and downward in a dose-dependent manner. The inhibitory effect of methysergide was reversed by washing, while that of ergotamine was not reversed. Apparent pA<SUB>2</SUB> values of LSD, ergotamine and methysergide were 9.17, 9.63 and 7.92, respectively. Contractile responses to 20 mM K<SUP>+</SUP> were not significantly influenced by these blocking agents even in the highest concentrations used. It may be concluded that an alpha-adrenergic mechanism is not involved in the genesis of serotonin-induced contractions and that serotonin acts directly on serotonergic receptors in canine cerebral arteries.
- 公益社団法人 日本薬理学会の論文
著者
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Toda Noboru
Department Of Pharmacology Shiga University Of Medical Science
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HAYASHI Shigehiro
Department of Pharmacology, Shiga University of Medical Sciences
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NAGASAKA Yasunori
Department of Pharmacology, Faculty of Medicine, Kyoto University
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FU Wang
Department of Pharmacology, Faculty of Medicine Kyoto University
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TODA Noboru
Department of Pharmacology, Faculty of Medicine Kyoto University
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NAGASAKA Yasunori
Department of Pharmacology, Faculty of Medicine Kyoto University
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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HAYASHI Shigehiro
Department of Pharmacology, Faculty of Medicine Kyoto University
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