Differences in Adrenergic Nerve and Receptor Function in Dog Internal Thoracic, Coronary and Mesenteric Arteries.
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概要
- 論文の詳細を見る
Isolated dog internal thoracic arteries (ITA) responded to norepinephrine and phenylephrine with concentration-related contractions, which were suppressed by prazosin, but not by yohimbine. Clonidine did not contract ITA. In coronary arterial strips, norepinephrine produced a relaxation. Isoproterenol relaxed coronary arterial strips contracted with serotonin but did not alter the tone of ITA. Forskolin and beraprost, an analog of prostaglandin I<SUB>2</SUB>, relaxed coronary and ITA strips to a similar extent. The β-adrenoceptor density, assayed by [<SUP>3</SUP>H]dihydroalprenolol binding, was markedly less in ITA than in coronary arteries. Nicotine and transmural electrical stimulation did not alter the tension of ITA. Immunohistochemical study indicated that nerve fibers containing tyrosine hydroxylase immunoreactivity were markedly less in ITA than in coronary and mescnteric arteries. These results indicate that β-adrenoceptor function and adrenergic innervation are considerably reduced in dog ITA. Norepinephrine-induced vasocontraction appears to be mediated by α<SUB>1</SUB>-adrenoceptors in the arteries.
- 公益社団法人 日本薬理学会の論文
著者
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Mori Atsumi
Second Department Of Surgery Shiga University Of Medical Science
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Okamura Tomio
Department Of Pharmacology
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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Shiraishi Shoichiro
Department of Pharmacology, Shiga University of Medical Science
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