Role of nitric oxide in non-adrenergic, non-cholinergic nerve-mediated relaxation in dog duodenal longitudinal muscle strips.
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概要
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Transmural electrical stimulation caused a relaxation in the dog duodenal longitudinal muscle strips treated with atropine, phentolamine and propranolol, which was abolished by tetrodotoxin. The relaxation was suppressed by oxyhemoglobin and L-N<SUP>G</SUP>-nitro-arginine (L-NA), but not influenced by D-NA. Inhibition by L-NA was reversed by L-arginine, but not by D-arginine. The response to transmural electrical stimulation was similar to that caused by nitric oxide or nitroglycerin. Nitric oxide appears to participate importantly in non-adrenergic, non-cholinergic nerve-mediated relaxation.
- 公益社団法人 日本薬理学会の論文
著者
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Okamura Tomio
Department Of Pharmacology
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Baba Hiroshi
Department Of Anesthesiology Faculty Of Medicine Niigata University
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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Baba Hiroshi
Department of Pharmacology, Shiga University of Medical Sciences
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