Protection by Hypothermia of Hypoxia-Induced Ingibition of Neurogenin Vasodilation in Porcine Cerebral Arteries
スポンサーリンク
概要
- 論文の詳細を見る
Porcine cerebral arterial strips denuded of the endothelium responded to transmural electrical stimulation (5 Hz for 40 s) with a relaxation, which was abolished by tetrodotoxin and N G-nitro-<sc>L</sc>-arginine, a NO synthase inhibitor. Lowering the temperature of the bathing media from 37°C to 33°C or 25°C potentiated the response to nerve stimulation, but did not affect relaxations induced by NO applied exogenously. Hypoxia suppressed the stimulation-induced relaxation at 37°C, but hypothermia blunted the inhibitory effect of hypoxia in a temperature-dependent manner. It is concluded that hypothermia augments vasodilatation associated with nitroxidergic (nitrergic) nerve activation possibly by increasing the production of NO from <sc>L</sc>-arginine and, in addition, prevents impairment of NO production by hypoxia. These mechanisms likely explain how hypothermia protects nerve cells against hypoxia. Inhibitions of cyclic GMP phosphodiesterase and of superoxide production by hypoxia do not seem to participate in the action of hypothermia. Mechanisms underlying its protective action remain to be ascertained.
- 社団法人 日本薬理学会の論文
- 2003-06-01
著者
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TANAKA Toshiki
Department of Neurosurgery, Asahi University Murakami Memorial Hospital
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Toda Noboru
Department of Pharmacology, Sniga University of Medical Sciences
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OKAMURA Tomio
Department of Pharmacology, Shiga University of Medical Science
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Okamura T
Department Of Pharmacology Shiga University Of Medical Science
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AYAJIKI Kazuhide
Department of Pharmacology, Shiga University of Medical Science
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Tanaka Toshiki
Department Of Applied Chemistry Faculty Of Engineering Nagoya Institute Of Technology
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Tanaka Toshiki
Department Of Pharmacology Shiga University Of Medical Science
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Okamura Tomio
Department Of Pharmacology
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Toda N
Department Of Pharmacology Shiga University Of Medical Science
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Okamura T
Shiga Univ. Medical Sci. Ohtsu Jpn
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FUJIOKA Hideyuki
the Department of Pharmacology, Shiga University of Medical Science
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Toda Noboru
Department Of Pharmacology Shiga University Of Medical Science
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FUJIOKA Hideyuki
Department of Pharmacology, Shiga University of Medical Science
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Fujioka Hideyuki
Department Of Pharmacology Shiga University Of Medical Science
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Ayajiki Kazuhide
Department Of Pharmacology Shiga University Of Medical Science
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Fujioka Hideyuki
Department Of Bioscience And Biotechnology Graduate School Of Bioresource And Bioenvironmental Scien
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Ayajiki Kazuhide
Department Of Pharmacy School Of Pharmacy Hyogo University Of Health Sciences
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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