Inhibition of Human Chymase by Suramin
スポンサーリンク
概要
- 論文の詳細を見る
Chymase is a chymotrypsin-like protease localized in mast cells in complexes with heparin. In the present study, we demonstrated that suramin, a hexasulfonated naphthylurea used as an anti-cancer drug, inhibits the activity of purified human chymase in vitro. The inhibition was ionic-strength-dependent. It was observed that suramin competed with heparin-Sepharose gel for binding to chymase and the inhibition of chymase activity by suramin was partially impaired by heparin. Our results show that suramin may become a prototype of a new type of chymase inhibitor because of its unique character.
- 社団法人 日本薬理学会の論文
- 1999-12-01
著者
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Takai Shinji
Department Of Cardiology Kouseikai Takeda Hospital
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MIYAZAKI Mizuo
Department of Pharmacology, Osaka Medical College
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Sawada Takahisa
京都第一赤十字病院 循環器科
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Takai Shinji
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
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TAKAO Kazumasa
Department of Pharmacology, Osaka Medical College
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ISHIHARA Takafumi
Discovery Research Division, Santen Pharmaceutical Co., Ltd.
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MITA Shiro
Discovery Research Division, Santen Pharmaceutical Co., Ltd.
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Takai Shinji
Department Of Pharmacology Osaka Medical College
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Takai S
Department Of Cardiology Kyoto First Red Cross Hospital
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Mita Shiro
Discovery Research Division Santen Pharmaceutical Co. Ltd.
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Takao Kazumasa
Department Of Pharmacology Osaka Medical College
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Ishihara Tadashi
Department Of First Internal Medicine Osaka Medical College
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Tamaki Shunichi
Department Of Cardiology Kouseikai Takeda Hospital
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Miyazaki Mizuo
Department Of Pharmacoldgy Osaka Medical College
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Takai Shinji
Department Of Animal Hygiene School Of Veterinary Medicine And Animal Sciences Kitasato University
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Tanda Syuji
Department Of Cardiology Kouseikai Takeda Hospital
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