Possible Roles of Cardiac Chymase After Myocardial Infarction in Hamster Hearts
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概要
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The significance of cardiac chymase after myocardial infarction (MI) was evaluated using a hamster model of MI. At 1, 3, 7, 14, 28 and 56 days after MI, tissues were removed for measurements of angiotensin-converting enzyme (ACE) and chymase activities. The mean infarct size 3 days after left coronary artery ligation was 47.3 ± 5.9% of the left ventricle circumference. The ratio of left ventricle weight to body weight was significantly increased from 3 days after MI. The level of plasma renin activity in the MI hamsters was significantly increased at the early phase of MI (1 - 3 days), while no significant changes in plasma ACE activity were observed. The ACE activity in the infarcted left ventricle was significantly increased starting from 3 days after MI and this increase was sustained up to 28 days. The chymase activity in the infarcted left ventricle was significantly increased starting from 1 day after MI and this increase was sustained up to 56 days. The number of chymase-positive mast cells in the infarcted left ventricle was significantly higher than in the sham group 3 and 7 days after operation. Treatment with an angiotensin (Ang) II type 1 receptor antagonist (candesartan cilexetil, 10 mg/kg per day) starting 3 days before the induction of MI significantly reduced the mortality rate during 14 days of observation following MI, whereas treatment with an ACE inhibitor (lisinopril, 20 mg/kg per day) did not. A significant improvement in hemodynamics (maximal negative and positive rates of pressure development, left ventricular systolic pressure and end-diastolic pressure, mean arterial blood pressure) was observed by the treatment with candesartan cilexetil, but not with lisinopril, 3 and 14 days after MI. These results suggested that Ang II produced by chymase may participate in the pathophysiologic state after MI in hamsters.
- 2001-06-01
著者
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Takai Shinji
Department Of Cardiology Kouseikai Takeda Hospital
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Sakaguchi Minoru
大阪薬科大学
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Sakaguchi Minoru
Intensive Grazing Research Team National Agricultural Research Center For Hokkaido Region National A
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JIN Denan
Department of Pharmacology, Osaka Medical College
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MIYAZAKI Mizuo
Department of Pharmacology, Osaka Medical College
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Yamada Mayumi
Department of Cardiology, Kyorin University School of Medicine
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Yamada M
Department Of Pharmacology Osaka Medical College
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Yamada Mayumi
Department Of Cardiology Kyorin University School Of Medicine
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Takai Shinji
Department Of Pharmacology Osaka Medical College
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SAKAGUCHI Masato
Department of Pharmacology, Osaka Medical College
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Jin Denan
Department Of Pharmacology Osaka Medical College
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Sakaguchi M
Laboratory Of Cell Biology Osaka University Of Pharmaceutical Sciences
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Yamada M
Department Of Medical Biochemistry Graduate School Of Medicine Tokyo Medical And Dental University
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YAO Yulin
Discovery Research Division, Santen Pharmaceutical Co., Ltd.
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Miyazaki Mizuo
Department Of Pharmacology Osaka Medical College Takatsuki City
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Miyasaka Yoko
Cardiovascular Division Department Of Medicine Ii Kansai Medical University
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Yao Yulin
Discovery Research Division Santen Pharmaceutical Co. Ltd.
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Miyazaki Mizuo
Department Of Pharmacoldgy Osaka Medical College
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Tanda Syuji
Division Of Hypertension And Nephrology Department Of Internal Medicine Kyoto Prefectural University
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Sakaguchi Masato
Department Of Materials Science & Technology Nagoya Institute Of Technology
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Miyasaka Yoko
Second Department Of Internal Medicine Division Of Cardiology Kansai Medical University
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Mori Yasukiyo
Division Of Cardiology And Nephrology Department Of Medicine Kyoto Prefectural University Of Medicin
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Takai Shinji
Department Of Animal Hygiene School Of Veterinary Medicine And Animal Sciences Kitasato University
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