Angiotensin II Type 1 Receptor Antagonist, TCV-1 16, Prevents Neointima Formation in Injured Arteries in the Dog
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effect of an angiotensin (Ang) II antagonist, (+/-)-1-(cyclohexyloxy- carbonyloxy)-ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116), on neointima formation in dog artery injured by a balloon catheter. Dogs were orally treated with 10 mg/kg TCV-116 or placebo twice a day for 5 weeks. After treatment with these drugs for 1 week, the right carotid artery was injured by a balloon catheter. The left carotid artery was regarded as the control. In the group treated with placebo, neointima formation in the injured arteries was observed. The activities of angiotensin converting enzyme (ACE) and chymase in the injured carotid arteries were increased 2.56- and 3.26-fold compared with those in the non-injured arteries, respectively. The neointimal area in dogs treated with placebo and TCV-116 were 0.51±0.07 and 0.21±0.07 mm2, respectively, and this difference was significant. In conclusion, an Ang II antagonist, TCV-116, prevented neointima formation by blocking the action of Ang II generated by both ACE and chymase in the injured arteries.
- 社団法人 日本薬理学会の論文
- 1999-04-01
著者
-
Takai Shinji
Department Of Cardiology Kouseikai Takeda Hospital
-
MIYAZAKI Mizuo
Department of Pharmacology, Osaka Medical College
-
Takai Shinji
Department Of Cardiovascular Medicine Kyoto Prefectural University School Of Medicine
-
SHIOTA Naotaka
Department of Pharmacology, Osaka Medical College
-
SAKONJO Hiroshi
Department of Pharmacology, Osaka Medical College
-
Shiota Naotaka
Department Of Pharmacology Osaka Medical Colleg
-
Sakonjo Hiroshi
Department Of Pharmacology Osaka Medical College
-
Miyazaki Mizuo
Department Of Pharmacoldgy Osaka Medical College
-
Takai Shinji
Department Of Animal Hygiene School Of Veterinary Medicine And Animal Sciences Kitasato University
関連論文
- Erythropoietin in Patients With Acute Coronary Syndrome and Its Cardioprotective Action After Percutaneous Coronary Intervention
- PJ-713 Seasonal Mortality Variation in Out-of-hospital Cardiac Arrest : Analysis from AMI-Kyoto Multi-Center Risk Study Database(PJ120,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-383 Predictors of In-Hospital Prognosis after Primary Percutaneous Coronary Intervention for Repeat Myocardial Infarction : Insights from the AMI-Kyoto Multi-Center Risk Study(PJ065,ACS/AMI (Clinical/Treatment) 3 (IHD),Poster Session (Japanese),The 73r
- PE-460 Prehospital Delay Time and the Rate of Ambulance User for Acute Myocardial Infarction were not Improved from 2000-2007 in Kyoto(PE077,ACS/AMI (Clinical/Diagnosis) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese C
- New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Chymase as an Important Target to Prevent Organ Damage
- A case of Takayasu's arteritis and aortic regurgitation, which presented much difficulty in the diagnosing process because of complicated osteomyelitis and non-typical manifestations
- FRS-036 In-hospital Prognostic Value of Crude Peak Creatine Kinase Measurement after Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction(FRS8,Novel Biomarkers and Pathophysiology of ACS (IHD),Featured Research Session (English),The
- Predictors of In-Hospital Outcome After Primary Percutaneous Coronary Intervention for Recurrent Myocardial Infarction
- Effects of Hospital Volume of Primary Percutaneous Coronary Interventions on Angiographic Results and In-Hospital Outcomes for Acute Myocardial Infarction
- OJ-204 Diminished Relation Between Hospital Volume of Primary PCI and In-Hospital Outcomes After AMI : Insights from the AMI-Kyoto Multi-Center Risk Study(Acute myocardial infarction, clinical (diagnosis / treatment)(04)(IHD),Oral Presentation (Japanese),
- Predictors of In-Hospital Prognosis After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction Requiring Mechanical Support Devices
- PJ-588 Rehabilitation after Angiogenic Cell Therapy for the Critical Limb Ischemia(PJ099,Exercise Test/Cardiac Rehabilitation 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-461 Aerobic Exercise in the Postoperative Cardiac Rehabilitation did not Deteriorate Renal Function in the Patients with Renal Failure(PJ078,Kidney/Renal Circulation/CKD 4 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- OJ-023 Intermediate Fixed Coronary Stenosis at a Site of Ergonovine-Provoked Spasm as a Predictor of the Long-Term MACE of CSA Patients(OJ04,Angina Pectoris (Basic, Clinical) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Jap
- Long-Term Angiotensin II Blockade May Improve Not Only Hyperglycemia but Also Age-Associated Cardiac Fibrosis
- PE-354 Aortic Valve Thickness Depends on Cardiac ACE Activity, not Blood Pressure in 1K-, 1K1C-, and 2K1C-Rabbit Models(PE060,Valvular Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-172 Introduction of Training Program in Basic Life Support can Improve the Survival after In-Hospital Cardiopulmonary Resuscitation(PE029,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japa
- OE-244 Protruding Atheroma in the Thoracic Aorta Detected by Multislice Computed Tomography Can Predict the Major Vascular Events(OE42,CT/MRI (Coronary/Vascular) 2 (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
- OE-235 Evidence of Plaque Neovascularization and Effects of Angiotensin Receptor Blocker in Cholesterol-Fed Monkey(OE40,Atherosclerosis, Basic 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-441 Virtual Histology Assessment of Attenuation Image Detected With 40MHz Gray-scale IVUS
- OE-307 Imidapril Attenuates MMP-9 Level More Effectively than Losartan in Patients with Acute Myocardial Infarction Treated by Primary-Percutaneous Coronary Intervention(Acute myocardial infarction, clinical(diagnosis/treatment)(02)(IHD),Oral Presentation
- PE-341 The Longitudinal Calcification Length in Multi-slice Computed Tomography May be Available to Detect the Coronary Artery Stenosis(CT/DSA-5 (I) PE57,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation S
- PE-317 Angiotensin Receptor 1 Blocker Inhibits Atherosclerotic Changes of Aortic Valve by Preserving Endothelial Cells and Inhibiting Transformation into Osteoblast Phenotype(Vascular heart disease/Pericarditis/Cardiac tumor-2 (M) PE53,Poster Session (Eng
- Evidence for Abundant Presence of Chymase-Positive Mast Cells in the Kidneys of Patients with Immunoglobulin A Nephropathy : Effect of Combination Therapy with Prednisolone and Angiotensin II Receptor Blocker Valsartan
- Inhibition of Human Chymase by Suramin
- Angiotensin II Type 1 Receptor Antagonist, TCV-1 16, Prevents Neointima Formation in Injured Arteries in the Dog
- IS005 Vascular Smooth Muscle Cell(VSMC)-Specific Overexpression of Angiotensin type2(AT2)Receptor Causes Endothelium-dependent Vasodilation via bradykinin/NO/cGMP pathway
- Inhibition of the Angiotensin II Type 1 Receptor by TCV-116: Quantitation by In Vitro Autoradiography
- P218 INTERACTION OF VASCULAR SMOOTH MUSCLE CELLS(VSMC) WITH EXTRACELLULAR MATRIX(ECM) : EFFECTS OF THE PURIFIED HUMAN CHYMASE ON VSMC ATTACHMENT TO ECM
- Intermediate Fixed Coronary Artery Stenosis at the Site of Ergonovine-Provoked Spasm as a Predictor of Long-Term Major Adverse Cardiac Events of Patients With Coronary Spastic Angina
- PJ-232 Postconditioning and Early ST-Segment Resolution in Patients with Acute Myocardial Infarction and Its Cardioprotective Action after Mechanical Reperfusion Therapy(PJ039,Cardiac Function (Clinical) 2 (M),Poster Session (Japanese),The 73rd Annual Sci
- PJ-340 The Relationship between Progression of Coronary Artery Plaques and Plaque Composition : Virtual Histology Intravascular Ultrasound Analysis(Intravascular endoscopy/Intravascular ultrasound(06)(I),Poster Session(Japanese),The 72nd Annual Scientific
- PE-507 Long term outcome of contrast-induced nephropathy after coronary angiography in diabetes patient with chronic kidney disease(Coronary revascularization, PCI(15)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circula
- Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters
- Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet
- Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats
- Anti-Atherosclerotic Effects of Dihomo-γ-Linolenic Acid in ApoE-Deficient Mice
- Chymase Inhibition Provides Pancreatic Islet Protection in Hamsters With Streptozotocin-Induced Diabetes
- Involvement of Vascular Angiotensin II-Forming Enzymes in the Progression of Aortic Abdominal Aneurysms in Angiotensin II-Infused ApoE-Deficient Mice
- Significance of chymase-dependent angiotensin II formation in the progression of human liver fibrosis
- Characterization of Recombinant Human Chymase Expressed in Escherichia coli
- OJ-062 Effect of Chymase Inhibition by NK-3201 on Hypoxia-Induced Left Ventricular Remodeling in Mice(Cardiovascular pharmacology, basic/clinical(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- The Significance of Chymase in the Progression of Abdominal Aortic Aneurysms in Dogs
- OJ-199 Role of Chymase and MMPs in Angiotensin II-induced Abdominal Aortic Aneurysms(Atherosclerosis, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- The Effects of Chymase on Matrix Metalloproteinase-2 Activation in Neointimal Hyperplasia after Balloon Injury in Dogs
- Tissue Angiotensin II Generating System by Angiotensin-Converting Enzyme and Chymase
- PJ-418 Effects of Chymase Inhibition on the Stenosis after Polytetrafluoroethylene Grafts Implantation(Restenosis, basic/clinical-5 (IHD) PJ71,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-278 Chymase Inhibition Prevents the Progression of Abdominal Aortic Aneurysm in Dogs(Peripheral circulation-5 (H) PE47,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Chymase Inhibition Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction in Rats
- Role of Chymase-Dependent Angiotensin II Formation in Regulating Blood Pressure in Spontaneously Hypertensive Rats
- The Effect of Chymase Inhibition on Arteriovenous Fistula Stenosis in Dogs (Peripheral Circulation/Vascular Disease 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- A Potent Chymase Inhibitor, Suc-Val-Pro-Phe(p)(OPh)(2), Suppresses the Development of Abdominal Aortic Aneurysm in Dogs(Valvular Heart Disease/Pericarditis/Cardiac Tumor 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Chymase-Dependent Transforming Growth Factor β on Peritoneal Adhesion Formation in a Rat Model
- PJ-043 An Antiarrhythmic Effect of A Chymase Inhibitor After Myocardial Infarction(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
- Impact of Chymase Inhibitor on Cardiac Function and Survival after Myocardial Infarction
- Oral Administration of a Specific Chymase Inhibitor, NK3201, Suppresses the Development of Aneurysmal Dilatation on Hamster Experimental Aneurysm Model
- Possible Roles of Angiotensin II-Forming Enzymes, Angiotensin Converting Enzyme and Chymase-like Enzyme, in the Human Aneurysmal Aorta
- Effect of Chymase Inhibitor on Vascular Proliferation
- Development of the Chymase Inhibitor as an Anti-Tissue-Remodeling Drug : Myocardial Infarction and Some Other Possibilities
- Recombinant Human Chymase Produced by Silkworm-Baculovirus Expression System : Its Application for a Chymase Detection Kit
- Oral Administration of a Novel Chymase Inhibitor, NK3201, Prevents Peritoneal Adhesion Formation in Hamsters
- Role of chymase in the development of aneurysmal formation; An experimental aneurysm model
- Possible Roles of Cardiac Chymase After Myocardial Infarction in Hamster Hearts
- PJ-743 A Comparison of Re-restenosis Results and Treatment Technique for Restenosis Lesion : Sirolimus-eluting Stent Versus Bare Metal Stent(Coronary revascularization, PCI-20, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-498 Assessment of cardiomyopathy with transient ballooning of the mid-base of the left ventricle. A new form of Takotsubo cardiomyopathy(Cardiomyopathy, basic/clinical-6 (M) PJ84,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting
- PJ-423 Restenosis Following Sirolimus-eluting Stent Implantation for Ostial Lesions(Restenosis, basic/clinical-5 (IHD) PJ71,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-114 Assessment of the Latent Congestive Heart Failure in Patients with Arterial Fibrillation Using I-123 BMIPP Myocardial Images(Nuclear cardiology-8 (I) PJ19,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- OJ-170 Assessment of Lipid Pool of Coronary Artery Plague. -Gray Scale IVUS vs. Virtual Histology IVUS(Echo/Doppler-4 (I) OJ29,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-131 Assessment of Coronary Artery Plaque in ACS Patient Using Virtual Histology IVUS(Acute coronary syndrome, basic/clinical-2 (IHD) OJ22,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-099 Limitation of Sirolimus Eluting Stent for Recurrent In-stent Restenosis(Coronary revascularization, PCI-5 (IHD) OJ17,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts
- PJ-333 Impact of Clinical Path on Self Esteem to Modify Lifestyle in Patients Undergoing Cardiac Catheterization : Using Questionnaire about Lifestyle(PJ056,Preventive Medicine/Epidemiology/Education 2 (H),Poster Session (Japanese),The 73rd Annual Scienti
- PE-549 Different Acute Effect of Continuous Positive Airway Pressure on Morning Blood Pressure in Obstructive Sleep Apnea(Hypertension, clinical(06)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Trans-Differentiation of Bone Marrow Monocyte-Lineage Cells to Endothelial-Like Cells and Reendothelialization on Injured Endothelium by MCP-1-Dependent Adhesion
- Coronary Microcirculation Disturbance in Takotsubo-like Transient Left Ventricular Dysfunction(Cardiomyopathy, Clinical 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-398 Nuclear Factor-κ B Activation Accelerates Cardiac Hypertrophy, Interstitial Fibrosis, and Oxidative Stress in Diabetic Rats Exposed to Intermittent Hypoxia(Chronic coronary heart disease/Remodeling-2, The 71st Annual Scientific Meeting of the Japan
- RELATIONSHIP AMONG ABNORMALITIES OF THE ULTRASONIC THREE-LAYERED APPEARANCE OF THE VENTRICULAR SEPTUM, MYOCARDIAL FATTY ACID METABOLISM AND PERFUSION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
- G-CSF Treatment Inhibits Neointimal Hyperplasia Associated with Endothelial Progenitor Cell Mobilization and Acceleration of Reendothelialization in Catorid Artery Injuty Model(Restenosis after Angioplasty, Basic/Clinical 5 (IHD), The 69th Annual Scientif
- Critical Role of Tyrosine Kinase PYK2 in eNOS Activation Revealed by Analysis of PYK2 Knockout Mice(Endothelium/NO 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-417 Tyrosine Kinase PYK2 activates eNOS and subsequently regulates Vascular Tonus and Angiogenesis, revealed by its Knock-out Mice(Endothelium/NO 5 (H) : OJ51)(Oral Presentation (Japanese))
- eNOS Activation and Its Vascular Functions Critically Requires the Presence of Tyrosine Kinase PYK2
- OJ-028 G-CSF Treatment Inhibits Neointimal Formation after Arterial Injury through the Mobilization of Endothelial Progenitor Cell and Acceleration of Reendothelialization(Restenosis, basic/clinical-1 (IHD) OJ5,Oral Presentation (Japanese),The 70th Annive
- Inhibition of Vascular Angiotensin-Converting Enzyme by Telmisartan via the Peroxisome Proliferator-Activated Receptor γ Agonistic Property in Rats
- Inhibition of Matrix Metalloproteinase-9 Activity by Trandolapril after Middle Cerebral Artery Occlusion in Rats
- Predictors of nonoptimal coronary flow after primary percutaneous coronary intervention with stent implantation for acute myocardial infarction
- Erythropoietin Prevention Trial of Coronary Restenosis and Cardiac Remodeling After ST-Elevated Acute Myocardial Infarction (EPOC-AMI) : A Pilot, Randomized, Placebo-Controlled Study
- Influence of previous myocardial infarction site on in-hospital outcome after primary percutaneous coronary intervention for repeat myocardial infarction
- 我が国における子馬のロドコッカス・エクイ感染症の疫学調査--1992年から1998年の108症例
- Trandolapril Reduces Infarction Area after Middle Cerebral Artery Occlusion in Rats
- SOME EXPERIMENTS ON ASCENDING OF CORYNEBACTERIUM RENALE IN MICE FROM URINARY BLADDER INTO KIDNEYS
- Significance of Angiotensin II Receptor Blocker Lipophilicities and Their Protective Effect against Vascular Remodeling
- Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats
- Genotypic Characterization of Virulent Rhodococcus equi Isolated from the Environment of Hokkaido Native Horses in Hakodate, Hokkaido
- Comparative Effects of Candesartan and Amlodipine in a Monkey Atherosclerotic Model
- Pharmacological Profiles of a Novel Non-peptide Angiotensin II Type I Receptor Antagonist HR720 In Vitro and In Vivo
- Cloning and Characterization of the fur Gene From Moraxella bovis
- Expression of Virulence-Associated Antigens of Rhodococcus equi Is Regulated by Temperature and pH
- Rhodococcus qui Infection in Foals -Current Concepts and Implication for Future Research-
- Clinical manifestations and effects of primary percutaneous coronary intervention for patients with delayed pre-hospital time in acute myocardial infarction
- Irbesartan Prevents Metabolic Syndrome in Rats via Activation of Peroxisome Proliferator-Activated Receptor γ