Effects of a Lipoxygenase Inhibitor, Panaxynol, on Vascular Contraction Induced by Angiotensin II

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概要

• 論文の詳細を見る

• We investigated whether a lipoxygenase inhibitor, panaxynol, affected the vascular contraction induced by angiotensin (Ang) II and the mean arterial pressure in spontaneously hypertensive rats (SHR). Panaxynol suppressed dose-dependently the contractile responses induced by 30 nM Ang II in isolated intact and endothelial cell-denuded aorta in the hamster. IC50 values in the intact and endothelial cell-denuded aorta were 23 and 20 μM, respectively. In SHR, the mean arterial pressure after injection of 30 and 60 mg/kg panaxynol was reduced, and the maximum hypotensive values were 23 and 48 mmHg, respectively. Thus, lipoxygenase products may affect the renin-angiotensin system.

• 社団法人 日本薬理学会の論文
• 1999-05-01

著者

• FUJITA Tadashi

  Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University, Graduate Sc

• Sakaguchi Minoru

  大阪薬科大学

• Sakaguchi Minoru

  Intensive Grazing Research Team National Agricultural Research Center For Hokkaido Region National A

• JIN Denan

  Department of Pharmacology, Osaka Medical College

• MIYAZAKI Mizuo

  Department of Pharmacology, Osaka Medical College

• Takai Shinji

  Department Of Pharmacology Osaka Medical College

• SAKAGUCHI Masato

  Department of Pharmacology, Osaka Medical College

• Jin Denan

  Department Of Pharmacology Osaka Medical College

• Baba Kimiye

  Department Of Pharmacognosy Osaka University Of Pharmaceutical Sciences

• Sakaguchi M

  Laboratory Of Cell Biology Osaka University Of Pharmaceutical Sciences

• IKEDA JUNKO

  Department of Home Economics, Kyoto Bunkyo Junior College

• KIRIMURA Kazuyoshi

  Department of Pharmacology, Osaka Medical College

• Fujita Tadashi

  Department Of Hygienic Chemistry Osaka University Of Pharmaceutical Sciences

• KIRIMURA Kazuyoshi

  Shiga Research Center, Nissei BILIS

• Ikeda Junko

  Department Of Home Economics Kyoto Bunkyo Junior College

• Miyazaki Mizuo

  Department Of Pharmacoldgy Osaka Medical College

• Kirimura Kazuyoshi

  Shiga Research Center Nissei Bilis

• Sakaguchi Masato

  Department Of Materials Science & Technology Nagoya Institute Of Technology

• Takai Shinji

  Department Of Animal Hygiene School Of Veterinary Medicine And Animal Sciences Kitasato University

• Fujita Tadashi

  Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine

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