Effect of Insulin-Like Growth Factor-I (IGF-I) on Femoral Bone Modeling in Growing Mice

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The time-dependent effects of daily dosing of IGF-I (1.21 mg/g) on the linear growth of the femur were investigated in mice. The femoral length and volume and the number of osteoclasts were significantly greater after IGF-I injection as compared to the non-injected control, suggesting that the IGF-I imbalance might cause a quick turnover cycle of the bone resulting in the altered femoral modeling.
社団法人　日本実験動物学会の論文
2002-10-01

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