Effect of alendronate on resorption of transplanted bone in mice
スポンサーリンク
概要
- 論文の詳細を見る
Alendronate, one of the bisphosphonates, is known to have an inhibitory effect on bone resorption. The purpose of study was to investigate the effects of alendronate on ectopic bone graft resotption and to determine the optimal dose in the mouse. In control group, segments of chopped tarsal bone were immersed in saline solution and auto-grafted. in experimental groups, the same bone segments were immersed in alendronate ranging in concentration from 10-4 to 10-6 M prior to transplantation. The grafted bone in the control group disappeared due to resorption by osteoclasts within 5 weeks. In the experimental groups, the area of bone tissue decreased by only 20-40% at 5 weeks post-operatively. The transplanted bone volume in alendronate-treated groups exhibited a tendency of dose-dependent increase, being highest in the 10-4 M group. The number of osteoclasts was significantly less in the alendronate-treated groups than in the controls. These results suggested that the alendronate inhibits resorption of ectopic bone graft at a concentration of 10-4 to 10-6 M.
- バイオメディカルリサーチプレスの論文
著者
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TOHMA Yuiko
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University, Graduate Sc
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TENJOU Kaoru
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sci
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TOKIMASA Chiyoko
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sci
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Tsutsui Keisuke
Department Of Orthodontics And Craniofacial Developmental Biology Graduate School Of Biomedical Scie
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Kohno Shinya
Department Of Materials Science Faculty Of Engineering Tohoku University
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Shigekawa Mao
Department Of Orthodontics And Craniofacial Developmental Biology Graduate School Of Biomedical Scie
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Matsuki Akira
Department Of Orthodontics And Craniofacial Developmental Biology Graduate School Of Biomedical Scie
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Kobayakawa Takashi
Department Of Orthodontics And Craniofacial Developmental Biology Graduate School Of Biomedical Scie
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Fujita Tadashi
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine
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MOTOKAWA Masahide
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University
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OHTANI Junji
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University
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TANNE Kazuo
Department of Oral Anatomy, Hiroshima University
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KAWATA Toshitsugu
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University
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KAKU Masato
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University
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TANNE Kazuo
Departntent of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University
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