EFFECT OF ASCORBIC ACID AND FERROUS IRON ON p-AMINOHIPPURATE ACCUMULATION BY RAT KIDNEY CORTICAL SLICES
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概要
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The effect of ascorbic acid and Fe<SUP>2+</SUP> on p-aminohippurate accumulation by rat kidney slices was examined. Ascorbic acid and Fe<SUP>2+</SUP> promoted lipid peroxidation of rat renal cortical slices was found to be dose related. Moreover, ascorbic acid (1.0 mM) and Fe<SUP>2+</SUP> (0.4 mM) increased tissue water and decreased the accumulation of p-aminohippurate. The addition of N, N-diphenyl-p-phenylenediamine (antioxidant) at the concentration of 1×10<SUP>-6</SUP> M recovered the accumulation of p-aminohippurate by about 43%. The apparent Km of p-aminohippurate uptake was increased by ascorbic acid and Fe<SUP>2+</SUP> with no change in the apparent V. These data suggest that ascorbic acid and Fe<SUP>2+</SUP> can cause a significant alteration in p-aminohippurate and water transport of renal cortical slices and that these effects may be, at least, partly due to the lipid peroxidative action of ascorbic acid and Fe<SUP>2+</SUP>.
- 社団法人 日本薬理学会の論文
著者
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Fujita Tadashi
Department Of Hygienic Chemistry Osaka University Of Pharmaceutical Sciences
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Fujimoto Yohko
Department Of Physiological Chemistry Osaka University Of Pharmaceutical Sciences
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YASUOKA Fujiko
Department of Hygienic Chemistry, Osaka College of Pharmacy
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Fujita Tadashi
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine
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FUJIMOTO Yohko
Department of Hygienic Chemistry, Osaka College of Pharmacy
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