EFFECT OF VARIOUS DIURETICS ON LIPID PEROXIDATION IN RAT RENAL CORTICAL MITOCHONDRIA AND IN THE SUPERNATANT
スポンサーリンク
概要
- 論文の詳細を見る
Effect of various diuretics on lipid peroxidation in rat kidney cortical mitochondria and in the supernatant (11, 000xg) was studied. Mersalyl (mercurial diuretic) markedly stimulated the lipid peroxidation in mitochondria and in the supernatant at a concentration of 1 mM, and metolazone (sulfonamide derivative, 1 mM) stimulated only that in the supernatant. Mersalyl-induced lipid peroxidation was markedly inhibited by several classical radical scavengers such as sodium diethyldithiocarbamate, 2, 6-di-tert-butyl phenol and N, N-diphenyl-p-phenylenediamine, but metolazone-induced lipid peroxidation was not inhibited by these scavengers. The addition of superoxide dismutase to the reaction mixture inhibited the mersalyl-induced lipid peroxidation, but did not inhibit the peroxidation by metolazone or ascorbate. These results suggest that lipid peroxidation by mersalyl is mediated by free radicals or superoxide anion, which were probably produced by mersalyl, and the mercurial diuretics-induced nephrotoxicity may be due to the lipid peroxidation in the kidney.
- 社団法人 日本薬理学会の論文
著者
-
Fujita Tadashi
Department Of Hygienic Chemistry Osaka University Of Pharmaceutical Sciences
-
Fujimoto Yohko
Department Of Physiological Chemistry Osaka University Of Pharmaceutical Sciences
-
Fujita Tadashi
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine
-
FUJIMOTO Yohko
Department of Hygienic Chemistry, Osaka College of Pharmacy
関連論文
- Cryopreservation of PDL Cells by Use of Program Freezer with Magnetic Field for Teeth Banking
- Influences of Reduced Masticatory Function on Learning and Memory Ability
- Effect of Alendronate on Osteoclast Differentiation and Bone Volume in Transplanted Bone
- Effect of Insulin-Like Growth Factor-I (IGF-I) on Femoral Bone Modeling in Growing Mice
- Analysis of Histochemically and Morphometrically in the Anterior Belly Digastric Muscle of Osteopetrotic (op/op) Mice
- Mechanism in Inhibitory Effects of Vitamin K_2 on Osteoclastic Bone Resorption : In Vivo Study in Osteopetrotic (op/op) Mice
- Congenital Osteoclast Deficiency in Osteopetrotic (op/op) Mice is Improved by Ovariectomy and Orchiectomy
- Midpalatal Suture of Osteopetrotic (op/op) Mice Exhibits Immature Fusion
- Inelastic Capture Ratio at Rest and Low-Energy Cross Sections of Σ^-p Scattering in the SU_6 Quark Model : Nuclear Physics
- Scattering Observables of the NN and YN Interactions in the SU_6 Quark Model : Nuclear Physics
- Scattering Observables Σ^+p System in the SU_6 Quark Model
- Scattering Observables of NN Interaction in the SU_6 Quark Model
- Comparative results of conservative treatments for isolated anterior talofibular ligament (ATFL) injury and injury to both the ATFL and calcaneofibular ligament of the ankle as assessed by subtalar arthrography
- Histochemical Studies on canine liver Homotransplantation (Antigenicity and Transplantation of the Liver)
- Effects of a Lipoxygenase Inhibitor, Panaxynol, on Vascular Contraction Induced by Angiotensin II
- Life Style-Related Diseases of the Digestive System : Endocrine Disruptors Stimulate Lipid Accumulation in Target Cells Related to Metabolic Syndrome
- EFFECT OF FLUORESCENT PRODUCTS FROM REACTION OF MALONALDEHYDE WITH PHOSPHATIDYLETHANOLAMINE ON LIPIDS IN PLASMA AND LIVER OF RATS
- EFFECT OF 4-PENTENOIC ACID ON LIPIDS IN PLASMA AND LIVER OF RATS
- Disulfide S-Monoxides Convert Xanthine Dehydrogenase into Oxidase in Rat Liver Cytosol More Potently Than Their Respective Disulfides(Pharmacology)
- EFFECT OF MERCURIALS ON LIPID PEROXIDATION IN RABBIT RENAL CORTICAL MITOCHONDRIA
- EFFECT OF ASCORBIC ACID AND FERROUS IRON ON p-AMINOHIPPURATE ACCUMULATION BY RAT KIDNEY CORTICAL SLICES
- THE ACCUMULATION OF ASCORBIC ACID AND IRON IN RAT LIVER MITOCHONDRIA AFTER LIPID PEROXIDATION
- EFFECT OF ASCORBIC ACID AND IRON ON LIPID CONTENT IN PLASMA AND LIVER OF RATS
- EFFECT OF 2-AMINO-3-ETHOXYCARBONYL-6-BENZYL-4, 5, 6, 7TETRAHYDROTHIENO [2, 3-C] PYRIDINE (TINORIDINE) ON FATTY ACID COMPOSITION OF LIVER LYSOSOMES FROM A VITAMIN E DEFICIENT DIET TO RATS
- EFFECT OF VARIOUS DIURETICS ON LIPID PEROXIDATION IN RAT RENAL CORTICAL MITOCHONDRIA AND IN THE SUPERNATANT
- Effects of Mandibular Advancement on Growth after Condylectomy
- Suspension “Hypokinesia/Hypodynamia” May Decrease Bone Mass by Stimulating Osteoclast Production in Ovariectomized Mice
- Microstructures of Cutting Chips of SUS430 and SUS304 Steels, and NCF 750 and 6061-T6 Alloys
- EFFECT OF CALCIUM INFUSION ON PLASMA LIPIDS IN DOGS
- Kidney Transplantation at Hirosaki Kidney Transplant Unit-Initial 5-Year Experience
- Inelastic Capture Ratio at Rest and Low-Energy Cross Sections of Σ^-p Scattering in the SU_6 Quark Model : Nuclear Physics
- Scattering Observables of the NN and YN Interactions in the SU_6 Quark Model : Nuclear Physics
- Effect of alendronate on resorption of transplanted bone in mice