Suspension “Hypokinesia/Hypodynamia” May Decrease Bone Mass by Stimulating Osteoclast Production in Ovariectomized Mice
スポンサーリンク
概要
- 論文の詳細を見る
This study was conducted to examine, in detail, the histological changes in the femurs of suspended ovariectomized (OVX) mice to assess the role of mechanical stress on bone remodeling. Suspended-OVX, suspended-sham-ope, nonsuspended-OVX, and non-suspended-sham-operated mice underwent operations 8 weeks after birth. Immediately after operation, hypokinesia/hypodynamia was created by a suspension harness for one week. Five specimens in each group were sacrificed 9 weeks after birth. The trabecular bone of the femurs in the suspended-OVX mice was removed and replaced extensively by bone marrow. The number of tartrate-resistant acid phosphatase (TRAP)-positive cells was larger in the suspended-OVX mice than in the remaining three groups. No significant differences in the number of TRAP positive cells were found between the suspended-sham-ope, nonsuspended-OVX and nonsuspended-sham-ope mice. The femurs of the OVX mouse with suspension “hypokinesia/hypodynamia” thus exhibits extensive trabecular bone loss in association with an increase of osteoclasts.
- 財団法人 学会誌刊行センターの論文
著者
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KAKU Masato
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University, Graduate Sc
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KAWATA Toshitsugu
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University, Graduate Sc
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TOKIMASA Chiyoko
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sci
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Kawata Toshitsugu
広島大学 医歯薬学総合研究科歯科矯正学
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河田 俊嗣
広島大学大学院医歯薬学総合研究科顎口腔頸部医科学講座歯科矯正学
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Tanne Kazuo
Department Of Orthodontics And Craniofacial Developmental Biology Hiroshima University Graduate Scho
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KAWASOKO Seiki
Department of Orhodontics, Hiroshima University School of Dentistry
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Niida Shumpei
Department Of Anatomy Faculty Of Dentistry Hiroshima University
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時政 智代子
Department Of Orthodontics And Craniofacial Developmental Biology Graduate School Of Biomedical Scie
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Fujita Tadashi
Department Of Hygienic Chemistry Osaka University Of Pharmaceutical Sciences
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Sugiyama Hiroki
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Fujita Tadashi
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine
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TOKIMASA Chiyoko
Department of Orthodontics Hiroshima University
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NIIDA Shumpei
Department of Orthodontics Hiroshima University
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TANNE Kazuo
Department of Oral Anatomy, Hiroshima University
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KAWATA Toshitsugu
Department of Orthodontics Hiroshima University
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KAWATA Toshitsugu
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University
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KAWASOKO Seiki
Department of Orthodontics Hiroshima University
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KAKU Masato
Department of Orthodontics Hiroshima University
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KAKU Masato
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University
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SUGIYAMA Hiroki
Department of Orthodontics Hiroshima University
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