Life Style-Related Diseases of the Digestive System : Endocrine Disruptors Stimulate Lipid Accumulation in Target Cells Related to Metabolic Syndrome

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概要

• 論文の詳細を見る

• Many reports indicated that endocrine disruptors (EDs) affect several hormonal functions in various living things. Here, we show the effect of EDs on lipid accumulation in target cells involved in the onset of metabolic syndrome. Treatment with nonylphenol and bisphenol A, typical EDs, stimulated the accumulation of triacylglycerol in differentiated adipocytes from 3T3-L1, preadipocytes, in time- and concentration-dependent manners. Up-regulation of gene expressions involved in lipid metabolism and metabolic syndrome were observed in adipocytes treated with EDs. Similarly, stimulatory effects of EDs were also observed on the human hepatoma cell line HuH-7. These observations indicate that exposure to EDs stimulates the lipid accumulation in target cells involved in the metabolic syndrome and may cause the dysfunction of those cells, resulting in induction of metabolic syndrome.

• 社団法人 日本薬理学会の論文
• 2007-10-20

著者

• WADA Koichiro

  Department of Pharmacology, Graduate School of Dentistry, Osaka University

• Tajima Atsushi

  横浜市立大学 医学研究科消化器内科

• Nakajima Atsushi

  Gastroenterology Division, Yokohama City University School of Medicine

• Nakajima Atsushi

  Division Of Gastroenterology Yokohama City University Graduate School Of Medicine

• Nakajima Atsushi

  理化学研究所ゲノム医科学研究センター 内分泌･代謝疾患チーム

• KAMISAKI Yoshinori

  Department of Pharmacology, Osaka University Graduate School of Dentistry

• Nakajima A

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Wada Koichiro

  Department Of Mathematical And Computing Sciences Tokyo Institute Of Technology

• Nakajima Atsushi

  Gastroenterology Division Yokohama University School Of Medicine

• SAKAMOTO Hirotada

  Department of Physiological Chemistry, Osaka University of Pharmaceutical Sciences

• NISHIKAWA Kenji

  Department of Physiological Chemistry, Osaka University of Pharmaceutical Sciences

• SAKUMA Satoru

  Department of Physiological Chemistry, Osaka University of Pharmaceutical Sciences

• FUJIMOTO Yohko

  Department of Physiological Chemistry, Osaka University of Pharmaceutical Sciences

• Sakuma Satoru

  大阪薬科大学 環境分子生理学研究室

• Sakuma Satoru

  Department Of Pediatrics Osaka City University Graduate School Of Medicine

• Fujimoto Yohko

  Department Of Physiological Chemistry Osaka University Of Pharmaceutical Sciences

• Nishikawa Kenji

  Department Of Physiological Chemistry Osaka University Of Pharmaceutical Sciences

• Kamisaki Yoshinori

  Department Of Clinical Pharmacology Faculty Of Medicine Tottori University

• Wada Koichiro

  Department Of Pharmacology Osaka University And Graduate School Of Dentistry

• 上崎 善規

  Dep. Of Pharmacology Graduate School Of Dentistry Osaka Univ. Jpn

• Nakajima A

  Keio University Faculty Of Science And Technology Department Of Chemistry

• Nakajima Atsushi

  Gastroenterology Division Yokohama City University School Of Medicine

• Sakamoto Hirotada

  Department Of Physiological Chemistry Osaka University Of Pharmaceutical Sciences

• Nakajima Atsushi

  Gastroenterology Division Yokohama City University Hospital

• FUJIMOTO Yohko

  Department of Hygienic Chemistry, Osaka College of Pharmacy

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