Lifestyle-Related Diseases of the Digestive System : A New In Vitro Model of Hepatitis C Virion Production : Application of Basic Research on Hepatitis C Virus to Clinical Medicine
スポンサーリンク
概要
- 論文の詳細を見る
The hepatitis C virus (HCV) is an enveloped virus with a single positive-strand RNA genome of about 9.6 kb. It is a major cause of liver disease worldwide. Clear understanding of the viral life cycle has been hampered by the lack of a robust cell culture system. While the development of the HCV replicon system was a major breakthrough, infectious virions could not be produced with the replicon system. Recently, several groups have reported producing HCV virions using in vitro systems. One of these is a replicon system, but with the special genotype 2a strain JFH-1. Another is a DNA transfection system, with the construct containing the cDNA of the known infectious HCV genotype 1b flanked by two ribozymes. The development of these models further extends the repertoire of tools available for the study of HCV biology, and in particular, they may help to elucidate the molecular details of hepatitis C viral assembly and release. This review discusses the progression of experimental strategies related to HCV and how these strategies may be applied to clinical medicine.
- 社団法人 日本薬理学会の論文
- 2007-10-20
著者
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Takeda Hiroshi
Department Of Medical Information Science Osaka University Graduate School Of Medicine
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Tajima Atsushi
横浜市立大学 医学研究科消化器内科
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Takahashi Hirokazu
Gastroenterology Division, Yokohama City University School of Medicine
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Nakajima Atsushi
Gastroenterology Division, Yokohama City University School of Medicine
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Takahashi Hirokazu
Division Of Gastroenterology Yokohama City University Graduate School Of Medicine
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YONEDA Masato
Gastroenterology Division, Yokohama City University Graduate School of Medicine
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SAITO Satoru
Gastroenterology Division, Yokohama City University Graduate School of Medicine
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Nakajima Atsushi
Division Of Gastroenterology Yokohama City University Graduate School Of Medicine
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Nakajima Atsushi
理化学研究所ゲノム医科学研究センター 内分泌･代謝疾患チーム
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Yoneda Masato
Division Of Gastroenterology Yokohama City University Graduate School Of Medicine
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Saito Satoru
Division Of Gastroenterology Yokohama City University Graduate School Of Medicine
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HELLER Theo
Liver Disease Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Inst
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LIANG Jake
Liver Disease Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Inst
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Nakajima A
Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Yoneda Masato
Department Of Gastroenterology Yokohama City University Graduate School Of Medicine
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Nakajima Atsushi
Gastroenterology Division Yokohama University School Of Medicine
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Liang Jake
Liver Disease Branch National Institute Of Diabetes And Digestive And Kidney Disease National Instit
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Heller Theo
Liver Disease Branch National Institute Of Diabetes And Digestive And Kidney Disease National Instit
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Saitoh Satoru
Gastroenterology Division Yokohama City University Graduate School Of Medicine
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Nakajima Atsushi
Gastroenterology Division Yokohama City University School Of Medicine
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Saito Satoru
Gastroenterological Center Yokohama City University Medical Center
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Nakajima Atsushi
Gastroenterology Division Yokohama City University Hospital
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Yoneda Masato
Gastroenterology Division Yokohama City University School Of Medicine
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Takahashi Hirokazu
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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