Role of Myeloid Cell Leukemia-1 in Cell Growth of Squamous Cell Carcinoma

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概要

• 論文の詳細を見る

• Myeloid cell leukemia-1 (Mcl-1), a member of the B-cell lymphoma-2 (Bcl-2) family, has been reported to be a critical survival factor in hematopoietic cells, yet little data exists for a role of Mcl-1 in human oral squamous cell carcinoma (SCC). A high level expression of Mcl-1 was observed in tumor cells of human primary SCC, lymph node metastasis tissues, and SCC cell lines. We manipulated expression of Mcl-1 protein in SCC cells by small interfering RNA (siRNA) for Mcl-1 and observed that Mcl-1 siRNA inhibited the growth of SCCs accompanied with apoptosis. Combination therapy of Mcl-1 siRNA and anti-tumor drug drastically inhibited the cell growth in comparison to that in each single treatment. In addition, phosphorylation of focal adhesion kinase (FAK) was decreased by treatment with Mcl-1 siRNA, resulting in decreases in phosphorylation of MEK1/2 and MAPK. The cell growth inhibition caused by knockdown of Mcl-1 was suggested to be mainly a result of suppression of proliferation via the inhibition of intracellular FAK/MAPK signaling pathways. These results imply a potentially important and novel role of the inhibition of Mcl-1 function by the use of specific siRNA in the treatment of SCC.

• 社団法人 日本薬理学会の論文
• 2009-07-20

著者

• Iida Seiji

  The First Department Of Oral And Maxillofacial Surgery Graduate School Of Dentistry Osaka University

• NAKAJIMA Atsushi

  Division of Gastroenterology, Yokohama City University Graduate School of Medicine

• NAKAJIMA Noriko

  Department of Pathology, National Institute of Infectious Diseases

• WADA Koichiro

  Department of Pharmacology, Graduate School of Dentistry, Osaka University

• Tajima Atsushi

  横浜市立大学 医学研究科消化器内科

• Namiki Atsushi

  Toho University School Of Medicine

• Nakajima Atsushi

  Division Of Gastroenterology Yokohama City University Graduate School Of Medicine

• Nakajima Atsushi

  理化学研究所ゲノム医科学研究センター 内分泌･代謝疾患チーム

• Namiki Atsushi

  Third Department Of Internal Medicine Toho University School Of Medicine Ohashi Hospital

• KAMISAKI Yoshinori

  Department of Pharmacology, Osaka University Graduate School of Dentistry

• Tajima Atsushi

  Division Of Gastroenterology Yokohama City University Graduate School Of Medicine

• Nakajima Noriko

  Department Of Pathology National Institute Of Infectious Diseases

• Wada Koichiro

  Department Of Mathematical And Computing Sciences Tokyo Institute Of Technology

• OKURA Masaya

  The First Department of Oran and Maxillofacial Surgery, Osaka University Graduate School of Dentistr

• MASUDA Tomotake

  The First Department of Oran and Maxillofacial Surgery, Osaka University Graduate School of Dentistr

• KOGO Mikihiko

  The First Department of Oran and Maxillofacial Surgery, Osaka University Graduate School of Dentistr

• NAGATA Masahide

  Department of Pharmacology, Graduate School of Dentistry, Osaka University

• KUSAYAMA Morio

  Department of Pharmacology, Graduate School of Dentistry, Osaka University

• Nakajima Atsushi

  横浜市立大学 医学研究科消化器内科学

• Namiki Atsushi

  The 3rd Department Of Internal Medicine Faculty Of Medicine University Of Toho

• Okura Masaya

  The First Department Of Oral And Maxillofacial Surgery Graduate School Of Dentistry Osaka University

• Kogo Mikihiko

  The First Department Of Oral And Maxillofacial Surgery Graduate School Of Dentistry Osaka University

• Kusayama Morio

  Department Of Pharmacology Graduate School Of Dentistry Osaka University

• Kamisaki Yoshinori

  Department Of Clinical Pharmacology Faculty Of Medicine Tottori University

• Masuda Tomotake

  The First Department Of Oral And Maxillofacial Surgery Graduate School Of Dentistry Osaka University

• Wada Koichiro

  Department Of Pharmacology Osaka University And Graduate School Of Dentistry

• Nagata Masahide

  Department Of Pharmacology Graduate School Of Dentistry Osaka University

• Wada Koichiro

  Department Of Pharmacology School Of Dentistry Osaka University

• 上崎 善規

  Dep. Of Pharmacology Graduate School Of Dentistry Osaka Univ. Jpn

• Kogo Mikihiko

  The First Department Of Maxillofacial Surgery Graduate School Of Dentistry Osaka University

• OKURA Masaya

  The First Department of Maxillofacial Surgery, Graduate School of Dentistry, Osaka University

• NAKAJIMA Atsushi

  Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University

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