Involvement of the NMDA-Nitric Oxide Pathway in the Development of Hypersensitivity to Tactile Stimulation in Dental Injured Rats
スポンサーリンク
概要
- 論文の詳細を見る
To investigate mechanisms in pathological pain conditions as the hyperalgesia and allodynia observed after dental surgery, we employed a rat dental-injury model involving the simultaneous pulpectomy to a lower incisor and extraction of an ipsilateral upper incisor. We found that hypersensitivity to tactile stimulation developed on both ipsilateral and contralateral sides in the dental-injured rats 5 days after the surgery and that this lasted for at least 30 days. Recovery from hypersensitivity to tactile stimulation was achieved by the intraperitoneal (i.p.) administration of MK-801 (0.05 mg/kg) or NG-monomethyl-<sc>L</sc>-arginine monoacetate (<sc>L</sc>-NMMA: 10 – 100 mg/kg), but not attained by NG-monomethyl-<sc>D</sc>-arginine monoacetate (<sc>D</sc>-NMMA: 100 mg/kg). This recovery effect of <sc>L</sc>-NMMA (50 mg/kg) was inhibited by pretreatment with <sc>L</sc>-arginine (600 mg/kg). In the trigeminal nucleus caudalis (SpVc), the changes in nitric oxide (NO) levels invoked by the intravenous (i.v.) administration of N-methyl-<sc>D</sc>-aspartate (NMDA; 10 mg/kg) were found to be significantly larger in the dental-injured rats than in sham-operated rats. The number of neuronal NO synthase (nNOS)-positive neurons increased in layers I-II and III-IV in the SpVc on both sides of the dental-injured rats. These results suggest that hypersensitivity to tactile stimulation developed following dental injury, and that NMDA receptor/NOS/NO production pathways in the SpVc may be involved in pathological conditions.
- 社団法人 日本薬理学会の論文
- 2002-10-01
著者
-
KAMISAKI Yoshinori
Department of Pharmacology, Osaka University Graduate School of Dentistry
-
YONEHARA Norifumi
Department of Pharmacology, Osaka University Faculty of Dentistry
-
Yonehara Norifumi
Department Of Dental Pharmacology Osaka University Graduate School Of Dentistry
-
AMANO Katsuhiko
Department of Pharmacology, Osaka University Graduate School of Dentistry
-
Amano Katsuhiko
Department Of Pharmacology Osaka University Graduate School Of Dentistry
-
Amano Katsuhiko
Department Of Molecular And Cellular Biochemistry Osaka University Graduate School Of Dentistry
-
Kamisaki Yoshinori
Department Of Pharmacology Osaka University Graduate School Of Dentistry
-
Kamisaki Yoshinori
Department Of Clinical Pharmacology Faculty Of Medicine Tottori University
関連論文
- Convergence and Divergence, a Concept for Explaining Drug Actions
- Role of Myeloid Cell Leukemia-1 in Cell Growth of Squamous Cell Carcinoma
- Effects of Topically Applied Capsaicin Cream on Neurogenic Inflammation and Thermal Sensitivity in Rats
- Involvement of GABAergic Systems in Manifestation of Pharmacological Activity of Desipramine
- Sensitive determination of nitrotyrosine in human plasma by isocratic high-performance liquid chromatography
- A Small-molecule Approach to Bone Regenerative Medicine in Dentistry
- A Possible Involvement of Monoaminergic and Opiodergic Systems in the Analgesia Induced by Electro-Acupuncture in Rabits
- Influence of serotonin receptor antagonists on substance P and serotonin release evoked by tooth pulp stimulation with electro-acupuncture in the trigeminal nucleus cudalis of the rabbit
- Interaction between nitric oxide and substance P on heat-induced inflammation in rat paw
- Nitric Oxide in the Rat Spinal Cord in Freund's Adjuvant-Induced Hyperalgesia
- Mechanisms of orofacial pain control in the central nervous system
- Involvement of the NMDA-Nitric Oxide Pathway in the Development of Hypersensitivity to Tactile Stimulation in Dental Injured Rats
- Signal transduction and transcriptional regulation during mesenchymal cell differentiation
- Life Style-Related Diseases of the Digestive System : Endocrine Disruptors Stimulate Lipid Accumulation in Target Cells Related to Metabolic Syndrome
- Nuclear Receptors as Targets for Drug Development : The Role of Nuclear Receptors During Neural Stem Cell Proliferation and Differentiation
- Roles of Oral Bacteria in Cardiovascular Diseases — From Molecular Mechanisms to Clinical Cases: Involvement of Porphyromonas gingivalis in the Development of Human Aortic Aneurysm
- Involvement of mitogen-activated protein kinase in peroxynitrite-induced cell death of human neuroblastoma SH-SY5Y cells
- Cyclic3',5'-Guanosine Monophosphate Synthesis Induced by Atrial Natriuretic Peptide, C-Type Natriuretic Peptide, and Nitric Oxide in the Rat Retina
- Roles of Oral Bacteria in Cardiovascular Diseases-From Molecular Mechanisms to Clinical Cases : Involvement of Porphyromonas gingivalis in the Development of Human Aortic Aneurysm
- SUBCELLULAR DISTRIBUTION OF ASCORBIC ACID IN RAT BRAIN
- Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma
- SYNTHESIS AND RELEASE OF ENDORPHINS IN TRIGEMINAL SENSORY NUCLEAR COMPLEX INDUCED BY TOOTH PULP STIMULATION IN THE RAT
- Effects of muscarinic agonists and antagonists on the negative chronotropic responses to the vagus nerve stimulation.
- Influence of Heat Stimulation on the Amount of Calcitonin Gene-Related Peptide and Neurokinin A in the Subcutaneous Space of the Rat Hind Instep.
- Algesiogenic and analgesic activities of synthetic substance P.