Effects of Topically Applied Capsaicin Cream on Neurogenic Inflammation and Thermal Sensitivity in Rats
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概要
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The effects of capsaicin cream on neurogenic inflammation and thermal nociceptive threshold were investigated in rats.Firstly, for topical application of capsaicin cream to hind paw, we shaped boots from dental cement to prevent the animals from licking off the drug.Capsaicin cream(1%) led to significant increases in the amounts of Evans blue and substance P(SP) released into the perfusate, and the former response was significantly suppressed by pretreatment with RP67580, an NK1-receptor antagonist, but not by treatment with an NK2-receptor antagonist.Subsequent electrical stimulation of the sciatic nerve resulted in a significant reduction in Evans blue and SP extravasation 24h after topical application of capsaicin cream.On the other hand, when capsaicin cream was repeatadly applied to both hind paws once a day, withdrawal latency for noxious heat stimulation decreased after 24h, and this thermal hyperalgesia was reversed 3 days later.These results suggest that capsaicin cream initially affects neurogenic inflammation mechanisms and then blocks the pain transmission mechanism.
- 社団法人 日本薬理学会の論文
- 2000-02-01
著者
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Ito Takashi
Department Of Physics University Of Tokyo
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KAWAI Yoichiro
Central Research Laboratory, Maruishi Pharmaceutical Co., Ltd.
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TAMURA Takashi
Central Research Laboratory, Maruishi Pharmaceutical Co., Ltd.
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Kawai Yoichiro
丸石製薬中央研究所
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Kawai Yoichiro
Central Research Laboratories Maruishi Pharmaceutical Co. Ltd
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Kawai Yasuaki
Division Of Adaptation Physiology Faculty Of Medicine Tottori University
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Itoh T
Department Of Physiology Kyoto Prefectural University Of Medicine
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Yoshimura Masakazu
Central Research Laboratory Of Maruishi Pharmaceutical Co. Ltd.
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Yoshimura M
Central Research Laboratories Maruishi Pharmaceutical Co. Ltd
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Yoshimura Masakazu
Central Research Laboratory Maruishi Pharmaceutical Co. Ltd.
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YONEHARA Norifumi
Department of Pharmacology, Osaka University Faculty of Dentistry
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Yonehara Norifumi
Div. Of Pharmacology Ohu Univ. School Of Pharmaceutical Sci. Jpn
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Yonehara Norifumi
Department Of Dental Pharmacology Osaka University Graduate School Of Dentistry
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Ito Takashi
Department Of Chemistry School Of Science The University Of Tokyo
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Ito T
Department Of Physiology Kyoto Prefectural University Of Medicine
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Tamura Takashi
School Of Health Sciences Kyorin University
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Tamura Takashi
Central Research Laboratories Maruishi Pharmaceutical Co. Ltd.
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Yoshimura Masakazu
Central Res. Lab. Of Maruishi Pharmaceutical Co. Ltd. 2-2-18 Imazunaka Tsurumi-ku Osaka 538-0042 Jpn
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Tamura Takashi
Central Research Laboratories Maruishi Pharmaceutical Co. Ltd
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Ito Takashi
Department of Chemical Engineering, Graduate School of Engineering, Nagoya University
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ITO Takashi
Department of Advanced Materials Chemistry, Graduate School of Engineering, Yokohama National University
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