Cleavage Specificity of Coxsackievirus 3C Proteinase for Peptide Substrate (2):Importance of the P2 and P4 Residues

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概要

• 論文の詳細を見る

• Coxsackievirus 3C proteinase (3C^<pro>) cleaves between Gln and Gly, but additional amino acids are required to constitute a cleavage site. To investigate the additional sequence requirements, cleavages of the peptide substrate, and its derivatives were examined. Substitutions of each residue from the P2 to P5 positions showed the importance of the P2 Phe and P4 Ala for recognition by 3C^<pro>.

• 社団法人日本農芸化学会の論文
• 1996-09-23

著者

• Komano T

  Kyoto Univ. Kyoto Jpn

• Komano Tohru

  Laboratory Of Biochemistry Department Of Agricultural Chemistry Kyoto University

• Komano Tohru

  京都大学

• TAMURA Takashi

  Central Research Laboratory, Maruishi Pharmaceutical Co., Ltd.

• Tamura T

  Department Of Biofunctional Chemistry Graduate School Of Natural Science And Technology Okayama Univ

• Tagiri Shigeki

  Laboratory Of Biochemistry Department Of Agricultural Chemistry Kinki University

• MIYASHITA Kinji

  Central Research Laboratories, Maruishi Pharmaceutical Co., Ltd.

• OKUNISHI Junji

  Central Research Laboratories, Maruishi Pharmaceutical Co., Ltd.

• UTSUMI Ryutaro

  Laboratory of Biochemistry, Department of Agricultural Chemistry, Kinki University

• HOTTA Kazusei

  Laboratory of Biochemistry, Department of Agricultural Chemistry, Kinki University

• SATOH Nobukatsu

  Central Research Laboratories, Maruishi Pharmaceutical Co., Ltd.

• Hotta Kazusei

  Laboratory Of Biochemistry Department Of Agricultural Chemistry Kinki University

• Okunishi Junji

  Central Research Laboratories Maruishi Pharmaceutical Co. Ltd.

• Utsumi R

  Department Of Bioscience And Biotechnology Graduate School Of Agriculture Kinki University

• Satoh Nobukatsu

  Central Research Laboratories Maruishi Pharmaceutical Co. Ltd.

• Miyashita Kinji

  Central Research Laboratories Maruishi Pharmaceutical Co. Ltd.

• Komano T

  Laboratory Of Cellular Biochemistry Division Of Applied Life Sciences Graduate School Of Agriculture

• Tamura Takashi

  Central Research Laboratories Maruishi Pharmaceutical Co. Ltd.

• Tamura Takashi

  Central Research Laboratories Maruishi Pharmaceutical Co. Ltd

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