Bacterial Signal Transduction Systems for Environmental Adaptation and Their Inhibitors
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概要
- 論文の詳細を見る
Bacterial two-component signal transduction systems (TCSs) play a pivotal role in environmental adaptation. In this minireview, two TCSs in Escherichia coli are clarified: the PhoP/PhoQ system, which senses extracellular Mg^<2+> and controls the expression of the genes for adaptation to environmental Mg^<2+> deprivation(Mg^<2+> regulon); and EvgA/EvgS, a signal transduction system that activates expression of the drug efflux pump genes. Furthermore, based on the inhibition of YycF/YycG signal transduction in Bacillus subtilis, a novel strategy for developing a new class of antibacterial agents is described.
- 日本微生物生態学会の論文
著者
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Utsumi R
Department Of Bioscience And Biotechnology Graduate School Of Agriculture Kinki University
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Utsumi Ryutaro
Department Of Advanced Bioscience Kinki University
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