Molecular Interaction between Proteins Involved in EvgAS Signal Transduction of Escherichia coli
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概要
- 論文の詳細を見る
EvgA and EvgS constitute one two-component signal transduction system in Escherichia coli. Although probable signaling domains of these proteins have been estimated, the molecular mechanism of their inteaction remains to be elucidated. Here, we investigated protein to protein interactions between EvgA and EvgS and also between the EvgAS system and other related signaling pathways by means of surface plasmon resonance. EvgA and EvgS interacted directly and inhibition of phosphorylation of their functional domains abolished formation of the EvgAS complex. No interaction was observed either between EvgA and Bordetella BvgS or BvgA and EvgS. OmpR, a response regulator for the osmoregulative gene expression of E. coli, had similar but not identical behavior towards EvgS to that of EvgA. These results indicate that interaction between the signaling proteins is closely related to phosphorylation of the functional domain of the proteins.
- 社団法人日本農芸化学会の論文
- 1998-01-23
著者
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Masuda Takayuki
Department Of Cardiology And Hematology Fukushima Medical University
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YOSHIOKA Sachiko
Department of Chemistry, Faculty of Science, Saitama University
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Utsumi Ryutaro
Department of Agricultural Chemistry, Kinki University
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Yamazaki Katsuhide
Department of Agricultural Chemistry, Kinki University
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Tanabe Hiroyuki
Department of Agricultural Chemistry, Kinki University
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Masuda Takayuki
Department Of Agricultural Chemistry Kinki University
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Yoshioka Sachiko
Department Of Agricultural Chemistry Kinki University
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Utsumi Ryutaro
Department Of Advanced Bioscience Kinki University
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YAMASAKI Katsuhide
Department of Agricultural Chemistry, Kinki University
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KATOH Akinori
Department of Agricultural Chemistry, Kinki University
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TANASE Hiroyuki
Department of Agricultural Chemistry, Kinki University
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Katoh Akinori
Department Of Agricultural Chemistry Kinki University
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Yamazaki Katsuhide
Department Of Agricultural Chemistry Kinki University
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Tanabe Hiroyuki
Department Of Agricultural Chemistry Kinki University
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Yamasaki K
Meijo Univ. Nagoya Jpn
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