Molecular Mechanism of Transcriptional Cascade Initiated by the EvgS/EvgA System in Escherichia coli K-12
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概要
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Using an EvgS-active mutant (evgS1) in combination with gene deletions, we clarified the molecular mechanism of the transcriptional cascade of acid resistance and multidrug resistance genes initiated by the EvgS/EvgA two-component system in Escherichia coli, followed by sequential induction of the transcriptional regulators, YdeO and GadE. Overexpression of EvgA, the response regulator of the EvgS/EvgA system, is known to induce the expression of a number of acid resistance and multidrug resistance genes, in which the EvgA-YdeO-GadE circuit is involved, but the role of the sensor EvgS in this circuit has remained unsolved. Our results suggest that the transcriptional cascade initiated by the EvgS/EvgA system in fact functions for acid and drug resistance in E. coli.
- 社団法人 日本農芸化学会の論文
- 2009-04-23
著者
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Utsumi Ryutaro
Dep. Of Bioscience Graduate School Of Agriculture Kinki Univ.
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Utsumi Ryutaro
Department Of Advanced Bioscience Kinki University
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Utsumi Ryutaro
Department Of Bioscience Graduate School Of Agriculture Kinki University
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Eguchi Yoko
Department Of Bioscience Graduate School Of Agriculture Kinki University
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Eguchi Yoko
Department Of Applied Biological Chemistry Kinki University
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Itou Junji
Department Of Bioscience Graduate School Of Agriculture Kinki University
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