Effects of β-Casomorphin-5 on Passive Avoidance Response in Mice(Food & Nutrition Sience)

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The effects of intracerebroventricular (i.c.v.) injection of bovine β-casomorphin-5 (β-CM-5 : Tyr-Pro-Phe-Pro-Gly), a β-opioid agonist derived from milk β-casein, on step-down type passive avoidance tasks were investigated in mice. Intracerebroventricular administration of a high dose (10μg) of β-CM-5 produced a significant decrease in step-down latency. β-Funaltrexamine (5μg, i.c.v.) almost completely reversed the β-CM-5-induced shortening of step-down latency, although neither naltrindole (5ng, i.c.v.) nor nor-binaltorphimine (5μg, i.c.v.) had any significant influence on the effect of β-CM-5. Meanwhile, a low dose (0.5μg, i.c.v.) of β-CM-5 inhibited scopolamine (1mg/kg)-induced impairment of passive avoidance response. These results indicated that a high dose of β-CM-5 induces amnesia, whereas a low dose ameliorates scopolamine-induced amnesia.
社団法人日本農芸化学会の論文
2003-11-23