Effects of β-Casomorphins on Neuronal Survival in Culture of Embryonic Chick Dorsal Root Ganglion Neurons
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概要
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We studied the effects of β-casomorphins (β-CMs, μ-acting opioid peptides from milk protein β-casein) on survival of primary-cultured chick dorsal root ganglion neurons in the presence of nerve growth factor. β-CM-5 and β-CM-7 had potent neuronal survival-promoting activities. β-CM-4 amide (morphiceptin) and des-Tyr1-β-CM-7 also exhibited the similar promoting effects, although their effects were very weak. The promoting effect of β-CM-5 was prevented by co-administration of naloxone, or pretreatment with pertussis toxin. These results suggest that the neuronal survival-promoting effects of β-CMs might be mediated through opioid receptors coupled to G proteins.
- 社団法人 日本薬理学会の論文
- 2001-07-01
著者
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SAKAGUCHI Minoru
Laboratory of Cell Biology, Osaka University of Pharmaceutical Sciences
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MATSUMURA Eiko
Laboratory of Cell Biology, Osaka University of Pharmaceutical Sciences
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Matsumura Eiko
Laboratory Of Cell Biology Osaka University Of Pharmaceutical Sciences
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Sakaguchi Minoru
Laboratory Of Animal Physiology And Reproduction Department Of Animal Production National Agricultur
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FUJIMORI Takeshi
Laboratory of Cell Biology, Osaka University of Pharmaceutical Sciences
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SATOH Tomoko
Laboratory of Cell Biology, Osaka University of Pharmaceutical Sciences
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Fujimori Takeshi
Laboratory Of Cell Biology Osaka University Of Pharmaceutical Sciences
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Satoh Tomoko
Laboratory Of Cell Biology Osaka University Of Pharmaceutical Sciences
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