EFFECTS OF AMPHETAMINE, COCAINE, AND EPHEDRINE ON THE SEDATIVE AND HYPOTENSIVE ACTION OF RESERPINE IN RABBIT

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概要

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• The sedative and hypotensive effects of reserpine on experimental animals have been affirmed by many authors (1-3). Though the mechanism of action of reserpine to induce those effects was not fully elucidated, some experimental evidence revealed that the hypotensive effect of reserpine was derived from a central mechanism. It has already been shown that the pressor responses of the cat and dog to bilateral carotid occulsion or to stimulation of central end of the cut cervical vagus nerve are depressed by the intravenous injection of reserpine (1, 2). Bhargava and Borison (4) also showed that the pressor response to stimulation of the medulla oblongata was depressed by reserpine. Harrison and Goth (5) were the first to conclude that reserpine depressed the pressor response to stimulation of the hypothalamus. On the other hand, Anand et al. (6) and Schneider (7) could not show the depressing effect of reserpine on the hypothalamus, and it was supposed that the inconsistent results concerning the effects of reserpine on the pressor response to stimulation of the central nervous system were ascribable partially to the slow onset of the reserpine action. In their experiments, the effects of reserpine were obtained only 5 to 6 hours after the injection.<BR> It has also been shown by many authors (8-12) that the administration of reserpine releases catecholamines or serotonin from tissues, and consequently induces depletion of the amines. From the results that the injected reserpine disappeared from the circulating blood and tissues before the full development of its sedative and hypotensive effect (13, 14), the selective pharmacological action of reserpine was considered to be in some relation with the depletion of the naturally occurring amines from tissues.<BR> In the present experiments, the effects of reserpine on the pressor response to stimulation of the thalamic and hypothalamic nuclei were studied. Some of the results obtained have already been reported by Torii (15, 16), one of the authors.<BR> Brodie et al. (17) and Chessin et al. (18) showed that the previous injection of iproniazid, a potent in vitro monoamine oxidase inhibitor, modified the characteristic sedation by reserpine to a marked motor excitation in rats and rabbits. The present authors have already confirmed that the intraperitoneal injection of 0.1 to 1.0 mg/kg of reserpine often induced a motor excitement and occasionally even a convulsion in mice. In the present report, the effects of reserpine on the behavior of the rabbit pretreated with iproniazid were also studied. Furthermore, the effects of the indirect sympathomimetic drugs — such as cocaine, amphetamine and ephedrine, which are generally considered to have some inhibitory effect on monoamine oxidase activity — on the sedative and hypotensive action of reserpine were also tested.

著者

• SHIMAMOTO Kiro

  Department of Pharmacology, Faculty of Medicine, Kyoto University

• TORII HIROMICHI

  Department of Pharmacology, Faculty of Medicine, Kyoto university

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• EFFECTS OF AMPHETAMINE, COCAINE, AND EPHEDRINE ON THE SEDATIVE AND HYPOTENSIVE ACTION OF RESERPINE IN RABBIT
• THE EFFECT OF ADRENALINE AND NORADRENALINE ON THE SALIVARY SECRETION OF THE SYMPATHETICALLY DENERVATED GLANDS IN THE DOG
• PERIPHERAL ACTION OF THE GANGLION BLOCKINC AGENTS

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