THE EFFECT OF ADRENALINE AND NORADRENALINE ON THE SALIVARY SECRETION OF THE SYMPATHETICALLY DENERVATED GLANDS IN THE DOG

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It is usually accepted that the sympathetic innervation of the salivary glands in the dog is also motoric to the secretory activity as in the case of the parasympathetic innervation (1). The authors, in a preliminary report (2), showed evidence that the chief mode of the sympathetic innervation of the glands consists in the inhibitory effect on the secretory activity rather than the motoric effect in the dog, anesthetized with amytal sodium. The effect of the denervation of the submaxillary gland in the cat and the dog, which appears within 10 to 14 days after the extirpation of the superior cervical ganglion and causes an increased secretory response to the sympathomimetic amines, has already been observed by Bernard (3). But this denervation effect of the salivary gland was observed only with regards to the motoric activity of the amines. The present report deals with not only the motoric but also the inhibitory responses of the sympathetically denervated salivary glands of the dog to adrenaline and noradrenaline, as well as the motoric responses of the glands to cholinergic drugs.
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