Effect of alismol on adrenergic mechanism in isolated rabbit ear artery.
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概要
- 論文の詳細を見る
Effects of alismol, a sesquiterpenoid isolated from the rhyzome of <I>Alisma orientale, </I> on adrenergic mechanisms were examined in the isolated rabbit ear artery. Alismol (10<SUP>-6</SUP> to 10<SUP>-4</SUP>- M) inhibited the contraction of isolated rabbit ear artery by electrical stimulation of the perivascular nerves. The inhibition was concentrationdependent; at a concentration of 10<SUP>-4</SUP> M, the inhibition was 90% (n=8). Treatment with 10<SUP>-4</SUP> M alismol inhibited the increase in <SUP>3</SUP>H-noradrenaline (<SUP>3</SUP>H-NAd) release induced by electrical stimulation by 63±6%. Alismol at 10<SUP>-4</SUP> M did not affect the neuronal uptake of <SUP>3</SUP>H-NAd in the artery. Alismol at 10<SUP>-4</SUP> M slightly inhibited contractions induced by exogenously administered NAd. These results demonstrate that alismol inhibits the adrenergic neuro-effector mechanisms in rabbit ear artery, and they suggest that alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release.
- 公益社団法人 日本薬理学会の論文
著者
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YAMAHARA Johji
Kyoto Pharmaceutical University
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Fujimura Hajime
Kyoto College of Pharmacy
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Fujimura Hajime
Kyoto Pharmaceutical University
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KOBAYASHI Goro
Kyoto Pharmaceutical University
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Fujiwara Motohatsu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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KURAHASHI Kazuyoshi
Department of Pharmacology, Faculty of Medicine, Kyoto University
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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KURAHASHI Kazuyoshi
Department of Pharmacology, Faculty of Medicine, and Radioisotope Research Center
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