POSSIBLE INVOLVEMENT OF β_2-ADRENOCEPTORS IN HYPERTHERMIC EFFECT OF l-EPHEDRINE IN RATS
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概要
- 論文の詳細を見る
The experiments were conducted in order to examine the mechanism of hyperthermia induced by l-ephedrine in rats. β-Adrenoceptor agonists have been known to enhance normal body temperature. Therefore, the effect of various β-adrenoceptor agonists on body temperature in rats was examined to clarify the mechanism of action of l-ephedrine. The results showed that drugs with β_2-adrenoceptor agonist activity and l-ephedrine caused hyperthermia in rats and this effect was selectively inhibited by pretreatment of animals with propranolol (a mixed β-adrenoceptor antagonist) or butoxamine (a selective β_2-adrenoceptor antagonist). These results suggest that hyperthermic action of l-ephedrine may largely be due to its effect on β_2-adrenoceptors.
- 公益社団法人日本薬学会の論文
著者
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YAMAHARA Johji
Kyoto Pharmaceutical University
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Fujimura Hajime
Kyoto College of Pharmacy
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Sawada T
Faculty Of Pharmaceutical Sciences Kanazawa University
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KIMATA MOTOKI
Kyoto Pharmaceutical University
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SAWADA TOKUNOSUKE
Kyoto Pharmaceutical University
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Fujimura Hajime
Kyoto Pharmaceutical University
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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SAWADA TOKUNOSUKE
Kyoto College of Pharmacy
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