Bioactive Saponins and Glycosides. VII. On the Hypoglycemic Principles from the Root Cortex of Aralia elata SEEM. : Structure Related Hypoglycemic Activity of Oleanolic Acid Oligoglycoside
スポンサーリンク
概要
- 論文の詳細を見る
The hypoglycemic component, elatoside E, was isolated from the root cortex of Aralia elata SEEM. (Araliaceae) together with elatoside F and eight known oleanolic acid glycosides, elatosides A and C, oleanolic acid 3-O-[α-L-arabinofuranosyl (1→4)]-β-D-glucopyranosiduronic acid, oleanolic acid 3-O-β-D-glucopyranosiduronic acid, stipuleanosides R_1 and R_2,and chikusetsusaponins IV and IVa. The structures of elatosides E and F were determined on the basis of chemical and physicochemical evidence as oleanolic acid 3-O-[β-D-xylopyranosyl(1→2)][β-D-glucopyranosyl (1→3)]-α-L-arabinopyranoside and its 28-O-β-D-glucopyranosyl ester, respectively.The hypoglycemic activity of oleanolic acid and nine oleanolic acid oligoglycosides from the root cortex of Aralia elata was determined by monitoring inhibition effect on the elevation of plasma glucose level by oral sucrose tolerance test in rats, and some structure-activity relationships of oleanolic acid glycoside were obtained.
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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MURAKAMI Nobutoshi
Kyoto Pharmaceutical University
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YAMAHARA Johji
Kyoto Pharmaceutical University
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HARADA Emiko
Research and Education Center for Genetic Information, Nara Institute of Science and Technology
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村上 啓寿
阪大院薬:presto
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Yamahara J
Kyoto Pharmaceutical University
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HARADA Emiko
Kyoto Pharmaceutical University
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Harada E
Research And Education Center For Genetic Information Nara Institute Of Science And Technology
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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