Bioactive Saponins and Glycosides. XIV. Structure Elucidation and Immunological Adjuvant Activity of Novel Protojujubogenin Type Triterpene Bisdesmosides, Protojujubosides A, B, and B_1,from the Seeds of Zizyphus jujuba var. spinosa (Zizyphi Spinosi Semen

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概要

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• Following the elucidation of jujubosides A_1 and C and acetyljujuboside B, novel protojujubogenin type triterpene bisdesmosides, protojujubosides A, B, and B_1,were isolated from Zizyphi Spinosi Semen, the seeds of Zizyphus jujuba MILL. var. spinosa HU. The structures of protojujubosides A, B, and B_1 were determined on the basis of chemical and physicochemical evidence, which included the conversion of protojujubosides to known jujubosides using enzymatic hydrolysis. Protojujubosides A and jujubosides A, B, and C were found to show potent immunological adjuvant activity.

• 公益社団法人日本薬学会の論文
• 1999-12-15

著者

• MATSUDA Hisashi

  Kyoto Pharmaceutical University

• YOSHIKAWA Masayuki

  Kyoto Pharmaceutical University

• 村上 孝之

  Taiho Pharmaceutical Co. Ltd.

• MURAKAMI Toshiyuki

  Kyoto Pharmaceutical University

• YAMAHARA Johji

  Kyoto Pharmaceutical University

• IKEBATA Akira

  Kyoto Pharmaceutical University

• Yamahara J

  Kyoto Pharmaceutical University

• Yamazaki M

  School Of Pharmaceutical Sciences Kinki University

• Ikebata Akira

  Kyoto Pharmaceutical University Misasagi

• YAMAHARA JOHJI

  Kyoto College of Pharmacy

• MATSUDA HISASHI

  Kyoto College of Pharmacy

• Murakami Toshiyuki

  Kyoto Institute of Technology

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