EFFECTS OF C-TERMINAL OCTAPEPTIDE OF CHOLECYSTOKININ AND PROSTAGLANDINS ON ADRENERGIC FUNCTIONS IN THE GUINEA-PIG GALLBLADDER AND SPHINCTER OF ODDI
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概要
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Effects of C-terminal octapeptide of cholecystokinin (C<SUB>8</SUB>-CCK) and prostaglandins E<SUB>1</SUB>, E<SUB>2</SUB> and F<SUB>2α</SUB> on noradrenaline-induced responses and <SUP>3</SUP>H-noradrenaline release in the gallbladder and sphincter of Oddi of guinea pigs were examined. In the sphincter of Oddi, noradrenaline in low concentrations induced a relaxation which was blocked by either phentolamine or propranolol, while noradrenaline in high concentrations induced a contraction which was blocked by phentolamine. These results suggest the existence of excitatory and inhibitory α-receptors and inhibitory β-receptors in the sphincter of Oddi. In the gallbladder, the adrenergic receptors are α-excitatory and β-inhibitory. C<SUB>8</SUB>-CCK (10<SUP>-9</SUP> g/ml) potentiated both contractile and relaxing responses to noradrenaline, in the gallbladder. The same concentration of prostaglandins potentiated only contractile response to noradrenaline. In the sphincter of Oddi, noradrenaline-induced responses were not affected by C<SUB>8</SUB>-CCK and prostaglandins. Prostaglandins inhibited <SUP>3</SUP>H-efflux evoked by electrical stimulation, while C<SUB>8</SUB>-CCK had no effect on the <SUP>3</SUP>H-efflux from both preparations. These results suggest that C<SUB>8</SUB>-CCK enhances the contractile and relaxing responses to noradrenaline, and that prostaglandins act in a similar way on the postsynaptic response and, in addition, inhibit presynaptically the release of noradrenaline in the gallbladder. In the sphincter of Oddi, only prostaglandins inhibit the presynaptic event.
- 社団法人 日本薬理学会の論文
著者
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NAKATA Keigo
Department of Pharmacology, Faculty of Medicine, Kyoto University
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KURAHASHI Kazuyoshi
Department of Pharmacology, Faculty of Medicine, Kyoto University
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KURAHASHI Kazuyoshi
Department of Pharmacology, Faculty of Medicine, and Radioisotope Research Center
関連論文
- EFFECTS OF C-TERMINAL OCTAPEPTIDE OF CHOLECYSTOKININ AND PROSTAGLANDINS ON ADRENERGIC FUNCTIONS IN THE GUINEA-PIG GALLBLADDER AND SPHINCTER OF ODDI
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