Involvement of uptake2 mechanism in inactivation of noradrenaline released by tyramine under anoxic conditions in perfused rat heart.
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概要
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Effects of uptake<SUB>2</SUB> inhibition by corticosterone on tyramine-induced noradrenaline (NA) overflow under control, glucose-deprivation, anoxia and anoxia with glucose-deprivation were examined in perfused rat heart. Uptake<SUB>2</SUB> inhibition by corticosterone (100 μM) had no effect on the NA overflow under control and glucose-deprivation, but significantly augmented the NA overflow by about 40% and 25% under anoxia and anoxia with glucose-deprivation, respectively. These results indicate that the uptake<SUB>2</SUB> mechanism is at least in part responsible for the inactivation of NA under anoxic conditions in the perfused rat heart.
- 公益社団法人 日本薬理学会の論文
著者
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Fujiwara Motohatsu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Inoue Masafumi
Department Of Cardiology National Fukuyama Hospital
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KURAHASHI Kazuyoshi
Department of Pharmacology, Faculty of Medicine, and Radioisotope Research Center
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KURAHASHI Kazuyoshi
Department of Pharmacology, Faculty of Medicine, Kyoto University.
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HIFUMI Keijoh
Department of Pharmacology, Faculty of Medicine, Kyoto University.
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