INVOLVEMENT OF THE CHOLINERGIC MECHANISM IN DEPRESSION OF THE CAUDATE SPINDLE
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概要
- 論文の詳細を見る
Involvement of the cholinergic and catecholaminergic mechanisms in the caudate spindle recorded from the anterior and posterior sigmoid gyri was examined in cats. Physostigmine (0.01 to 0.1 mg/kg i.v.) abolished the appearance of the caudate spindle. These inhibitory effects were antagonized by the administration of atropine (0.25 to 1 mg/kg i.v.). The caudate spindle was inhibited by high frequency stimulation of the mesencephalic reticular formation: This inhibitory effect was antagonized by atropine. On the other hand, L-DOPA (25 to 50 mg/kg, i.v.), L-DOPA+MAO inhibitor and methamphetamine (0.5 to 5 mg/kg i.v.) did not influence the caudate spindle. These results suggest an involvement of cholinergic mechanism in depression of the caudate spindle.
- 社団法人 日本薬理学会の論文
著者
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Yamamoto Minoru
Department Of Ecosystem Engineering The University Of Tokushima
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Ishikawa Toshio
Department Of Mind-body Medicine Kohnodai Hospital National Center Of Neurology And Psychiatry
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YAMAMOTO Minoru
Department of Pharmacology, School of Medicine, Chiba University
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