Fluoride Supplement Affects Bone Mineralization in Young Rats

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概要

• 論文の詳細を見る

• Fluoride as a supplement can affect the structural integrity of bone. Fluoride that is incorporated in the mineral, substitutes for the hydroxyl group producing hydroxyfluorapatite crystals and presumed to increase bone strength by preventing resorption. Because of this, fluoride therapy has been carried out in clinical trials for the treatment of osteoporosis. Although fluoride renders the mineralized tissues resistant to resorption, the effects of fluoride on bone strength and cortical bone mass specially that of the developing bone has not yet been characterized. The purpose of the study was to analyze the effect of fluoride on developing teeth and bone in young rats through histomorphometry. Sixteen wistar rats were used and divided into two groups; non-fluoride supplemented (control) and fluoride-supplemented groups. Four weeks after, the rats were sacrificed and the mandible and femur were subjected to histological and histomorphometric analyses. No clinical difference was observed between the two groups. The amount of mineralized cartilage was higher in fluoride-supplemented group compared to the control group. However, the amount of new bone was lesser in fluoride-supplemented group compared to the control group. This histomorphometric analysis showed that during endochondral ossification, 10ppm fluoride administration caused some changes in calcified cartilage and bone mineralization in young rats.

• 硬組織再生生物学会の論文

著者

• 長塚 仁

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry & Pharmaceutical

• 長塚 仁

  岡山大学大学院医歯薬学総合研究科病態機構学講座口腔病理学分野

• 長塚 仁

  岡山大学 大学院医歯薬学総合研究科消化器腫瘍外科

• 長塚 仁

  岡山大学大学院医歯学総合研究科口腔病理病態学講座

• LEGEROS Racquel

  ニューヨーク大学

• Rivera Rosario

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry & Pharmaceutical

• Nagatsuka Hitoshi

  Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S

• Setsu Kojun

  Laboratories for Structure and Function Research, Faculty of Pharmaceutical science, Tokushima Bunri

• Inoue Masahisa

  Laboratories for Structure and Function Research, Faculty of Pharmaceutical Sciences, Tokushima Bunr

• LeGeros Racquel

  Department of Biomaterials and Biomimetics, College of Dentistry, New York University

• Inoue Miho

  Department of Biomaterials and Biomimetics, College of Dentistry, New York University

• Rivera Rosario

  Laboratories for Structure and Function Research, Faculty of Pharmaceutical Sciences, Tokushima Bunr

• Sathi Gulsan

  Laboratories for Structure and Function Research, Faculty of Pharmaceutical Sciences, Tokushima Bunr

• Akita Masahiko

  Laboratories for Structure and Function Research, Faculty of Pharmaceutical Sciences, Tokushima Bunr

• Inoue Masahisa

  Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri

• Inoue Masahisa

  徳島文理大学 薬学部機能形態学

• Hidetsugu Tsujigiwa

  Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni

• Tsujigiwa Hidetsugu

  徳島文理大学 薬学部機能形態学

• Tsujigiwa Hidetsugu

  Department Of Oral Pathology And Medicine Graduate School Of Medicine & Dentistry Okayama Univer

• Setsu K

  Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri

• Setsu Kojun

  Laboratories For Structure And Function Reaearch Faculty Of Pharmaceutical Sciences Tokushima Bunri

• Sathi Gulsan

  Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri

• Akita M

  Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri

• Legeros Racquel

  Department Of Biomaterials And Biomimetics New York University College Of Dentistry

• Legeros Racquel

  Department Of Biomaterials And Biomimetics College Of Dentistry New York University

• Legeros Racquel

  日本大学松戸歯学部 組織・発生・解剖学講座

• Akita Masahiko

  Laboratories For Structure And Function Reaearch Faculty Of Pharmaceutical Sciences Tokushima Bunri

• Nagatsuka Hitoshi

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi

• Tujigiwa Hidetugu

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi

• Tsujigiwa Hidetsugu

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry. Okayama Univers

• Rivera Rosario

  Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences

• Rivera Rosario

  Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri

• Setsu Kojun

  Laboratories For Structure And Function Research Faculty Of Pharmaceutical Science Tokushima Bunri U

• Tujigiwa Hidetugu

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry. Okayama Univers

• Setsu Kojun

  Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri

• Rivera Rosario

  College Of Dentistry University Of The East:graduate School Of Medicine Dentistry And Pharmaceutical

• Tujigiwa Hidetugu

  Dept. Of Oral Pathology Okayama Univ. Dental School.

• Inoue Masahisa

  Department Of Biomaterials And Biomimetics College Of Dentistry New York University

• Inoue Masahisa

  Department Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry A

• Inoue Masahisa

  Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri

• Tsujigiwa Hidetsugu

  Department Of Oral Pathology School Of Dentistry Okayama University

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