Transforming Growth Factor Beta (TGF-β) Gene Family Members in Developing and Neoplastic Odontogenic Tissues

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概要

• 論文の詳細を見る

• During the last decade, several molecules regulating tooth development have been identified (http://bite-it.helsinki.fi/). Especially members of the transforming growth factor beta (TGF-β) supergene family, structurally relates cytokines, are essential for teeth to develop. These include TGF-βs, activin A, bone morphogenetic proteins (BMPs), and their cell surface receptors. In addition, follistatin, an extracellular protein that interacts with activin and BMP signalling, appears to be an important mediator of associated inductive signals. Enhanced or impaired TGF-β/BMP signalling may play a role in odontogenic tumorigenesis. This review focuses on findings of our studies on the roles played by of TGF-β receptors, their ligands and extracellular modifiers during tooth development and in odontogenic tumours.

• 硬組織再生生物学会の論文

著者

• 長塚 仁

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry & Pharmaceutical

• 長塚 仁

  岡山大学大学院医歯薬学総合研究科病態機構学講座口腔病理学分野

• 長塚 仁

  岡山大学 大学院医歯薬学総合研究科消化器腫瘍外科

• 長塚 仁

  岡山大学大学院医歯学総合研究科口腔病理病態学講座

• Nagatsuka Hitoshi

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi

• Heikinheimo Kristiina

  Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku

• Mori Kazuhisa

  Department of Oral and Maxillofacial Surgery, The Nippon Dental University School of Dentistry at Ni

• Happonen Risto-Pekka

  Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku

• Heikinheimo Kristiina

  Department Of Oral And Maxillofacial Surgery Institute Of Dentistry University Of Turku:finland And

• Mori Kazuhisa

  Department Of Oral And Maxillofacial Surgery Ii School Of Life Dentistry At Niigata Nippon Dental Un

• Mori Kazuhisa

  2^<nd>department Of Oral And Maxillofacial Surgery The Nippon Dental University School Of Dent

• Happonen Risto-pekka

  Department Of Oral And Maxillofacial Surgery Institute Of Dentistry University Of Turku:finland And

• Mori Kazuhisa

  2^Department of Oral and Maxillofacial Surgery, The Nippon Dental University School of Dentistry at Niigata

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