Pheomelanin and Eumelanin of Malignant Melanomas and Melanosis in Oral Mucosa
スポンサーリンク
概要
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We attempted to elucidate the characteristics of melanin in malignant melanomas in oral mucosa by ultrastructural and energy-filtering transmission electron microscopy to examie the morphology and sulfur contents of the melanins in oral lesions of benign melanosis and malignant melanonmas. In lesions of melanosis of the oral mucosa, the essential pathological features are over-production of eumelanin and migration of melanin into keratinocytes. In lesions of malignant melanoma in situ, abnormal melanosomes consisting of many pleomorphic and ellipsoid forms are present. Sulfur distribution is increased, showing an increase in pheomelanin-like melanin. In invasive malignant melanoma the melanosomes assume irregular ellipsoid and spheroid forms, with the presence of compound melanosomes. The contents are eluted by alkali and most contain sulfur, indicating marked increase of pheomelanin-like melanosomes. The morphology and properties of melanosomes are important differential features for melanocyte-derived melanotic lesions including benign tumor, melanosis, and malignant melanoma. These findings habe great significance in the interpretation of early or precancerous lesios.
- 硬組織再生生物学会の論文
著者
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Nagatsuka Hitoshi
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Nagai Noriyuki
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Lee You-Jin
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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SHINNOU Yasuo
Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pha
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Sakae Toshiro
Department of Anatomy, Nihon University School of Dentistry at Matsudo
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Lee You-jin
Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Lee You-jin
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Shinnou Yasuo
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Shinno Yasuo
Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Lee You-jin
Department Of Electronics And Computer Engineering Hanyang University
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Takagi Tohru
Department Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry A
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Takagi Tohru
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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HIBI Kazuteru
Department of Oral Pathology, School of Dentistry, Okayama University
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Sakae Toshiro
Department Of Anatomy Ii Nihon University School Of Dentistry At Matsudo
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Sakae Toshiro
Department Of Oral Anatomy Nihon University School Of Dentistly At Matsudo
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Nagaoka Noriyuki
Department of Oral Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Ok
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Nagatsuka Hitoshi
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Dental School Okayama University
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Hibi Kazuteru
Dept. Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry And Ph
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Nagaoka Noriyuki
Department Of Applied Physics
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Shinnou Yasuo
Department Of Operative Dentistry Okayama University Graduate School Of Medicine Dentistry And Pharm
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Takagi Tohru
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Takagi Tohru
Department Of Biochemistry Faculty Of Dentistry Tokyo Medical And Dental University
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Hibi Kazuteru
Department Of Oral Pathology Okayama University Dental School
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Takagi Tohru
Department Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry A
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Takagi Tohru
Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni
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Takagi Tohru
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Takagi Tohru
Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni
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Takagi Tohru
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Lee You-Jin
Department of Electronic Engineering, Hanyang University, Seoul 133-791, Korea
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