Materials Design and Osteoinduction Characteristics of Biomimetic and Functionally Graded Apatites(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
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Bioabsorbable and functionally graded apatites (fg-HAp) were designed using bovine bone by the calcination and partial dissolution-precipitation methods. The fg-HAp ceramics had the specified surface structure and pore size distribution derived from living body. The pore structure of the ceramics with specific surface areas of 30-40 m^2\g^<-1> and porosities of 60-80% was divided into a macro-pore originating from spongy bone and a micro-pore related to body fluid permeation and blood permeability. Recombinant human bone morphogenetic protein-2 (rhBMP-2) solution was added to fg-HAp ceramics to obtain rhBMP-2-loaded fg-HAp (rhBMP-2/fg-HAp) ceramics exhibiting osteoinduction. The fg-HAp and rhBMP-2/fg-HAp ceramics were implanted to the subcutaneous tissue of rats. At 4 weeks after the implantation, for the fg-HAp, body fluid and albumin permeated the bulk region of the ceramics through the micro-pores, and surface- and bulk-degradations of the HAp grains proceeded. At 12 weeks, the fg-HAp ceramics were completely biodegraded and bioabsorbed. For the rhBMP-2/fg-HAp, at 4 weeks after the implantation, some pieces of fg-HAp were incorporated into the induced bone and fatty marrow, suggesting that osteoinduction occurred in conjunction with bone remodeling. The rhBMP-2/fg-HAp ceramics would be newly biomimetic materials with excellent blood permeability and osteoinduction.
- 硬組織再生生物学会の論文
著者
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Akasaka Tsukasa
Department Of Oral Health Science Graduate School Of Dental Medicine Hokkaido University
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Murata Masaru
北海道医療大学 歯 第2口腔外科
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Tazaki Junichi
Reconstructive Surgery For Oral And Maxillofacial Region School Of Dentistry Health Sciences Univ. O
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AKAZAWA Toshiyuki
Department of Materials Technology, Hokkaido Industrial Research Institute
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Murata Masaru
Department Of Oral Maxillofacial Surgery School Of Dentistry Health Sciences University Of Hokkaido
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Murata Masaru
2nd Department of Oral Surgery, School of Dentistry, Health Sciences University of Hokkaido
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Tazaki Junichi
2nd Department of Oral Surgery, School of Dentistry, Health Sciences University of Hokkaido
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Akazawa Toshiyuki
Department Of Oral Health Science Graduate School Of Dental Medicine Hokkaido University
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Tanaka J
National Inst. Materials Sci. Ibaraki
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Tanaka J
National Inst. Research In Inorganic Materials Ibaraki
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Akazawa Toshiyuki
Department Of Electrical And Electronic Engineering Niigata University
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Tazaki Junichi
2nd Department Of Oral Surgery School Of Dentistry Health Sciences University Of Hokkaido
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Murata Masaru
2nd Department Of Oral Surgery School Of Dentistry Health Sciences University Of Hokkaido
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Murata Masaru
Department Of Oral And Maxillofacial Surgery School Of Dentistry Health Sciences University Of Hokka
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Akazawa Toshiyuki
Department Of Biomedical Materials And Engineering Graduate School Of Dental Medicine Hokkaido Unive
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Akazawa Toshiyuki
Industrial Research Institute Industrial Technology Research Development Hokkaido Research Organizat
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Tazaki Junichi
Tokyo Institute Of Technology Graduate School Of Science And Engineering
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