Combination of Recombinant Human BMP-2 and Atelocollagen Implant with Cortical Perforations for Bone Augmentation

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概要

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• The purpose of this study was to determine whether bone augmentation could be obtained by the composite of recombinant human bone morphogenetic protein-2(rhBMP-2)and bioabsorbable atelocollagen, and to compare the efficacy of cortical perforations. The onlay implant was inserted into the space beneath the periosteum or the galea aponeurotica of 10-month old rats. A combination of the rhBMP-2/collagen subperiosteal implant with cortical perforations resulted in an initial acceleration of osteogenesis and the excellent augmented bone was connected directly with the original bone and exposed marrow space, whereas the rhBMP-2/collagen without perforations resulted in peripheral bone with many round acellular spaces in the middle area at initial stages. In subgaleal group, the rhBMP-2/collagen resulted in osteoblasts differentiation under the galea at 1 week. The carrier atelocollagen was completely replaced by bone tissue in the presence of rhBMP-2. Our present results indicate that the combination of cortical perforations to host bed and the rhBMP-2/collagen implant could accomplish remarkably success for bone augmentation. The rhBMP-2/collagen onlay implant may be clinically applicable even under the condition without the periosteum.

• 硬組織再生生物学会の論文

著者

• Minami Akio

  北海道大学保健管理センター

• Murata Masaru

  北海道医療大学 歯 第2口腔外科

• Murata M

  Okayama Univ. Okayama Jpn

• Qin Chun-lin

  Section Of Biochemistry The University Of Texas-houston Health Science Center Dental Branch

• MURATA Masaru

  Second Department of Oral Surgery, School of Dentistry, Health Sciences University of Hokkaido

• SATO Daisuke

  Second Department of Oral Surgery, School of Dentistry, Health Sciences University of Hokkaido

• NAGAI Noriyoki

  Department of Oral Pathology, School of Dentistry, Okayama University

• KUBOKI Yoshinori

  Department of Oral Biochemistry, School of Dentistry, Hokkaido University

• ARISUE Makoto

  Second Department of Oral Surgery, School of Dentistry, Health Sciences University of Hokkaido

• Kuboki Y

  Hokkaido University

• Kuboki Yoshinori

  Department Of Biochemistry Hokkaido University School Of Dentistry

• Kuboki Yoshinori

  Emeritus Professor Hokkaido University

• Qin Chun-lin

  Department Of Oral Pathology School Of Dentistry Okayama University

• Murata Masaru

  Department Of Oral Pathology School Of Dentistry Okayama University

• Murata Masaru

  Department Of Oral Maxillofacial Surgery School Of Dentistry Health Sciences University Of Hokkaido

• Arisue Makoto

  Health Sciences University of Hokkaido School of Dentistry

• Murata Masaru

  Second Department Of Oral And Maxillofacial Surgery School Of Dentistry Health Sciences University O

• Kuboki Yoshinori

  Dept. Of Oral Health Science Graduate School Of Dental Medicine Hokkaido University

• Kuboki Yoshinori

  Dept Biochem Sch Dentistry Hokkaido University

• Nagai Noriyuki

  Dept. Of Oral Pathology Okayama Univ. Dental School.

• Arisue Makoto

  Oral And Maxillofacial Surgery School Of Dentistry Health Sciences Univ. Of Hokkaido

• Arisue Makoto

  Second Department Of Oral Surgery School Of Dentistry Health Sciences University Of Hokkaido

• Arisue Makoto

  Second Department Of Oral And Maxillofacial Surgery School Of Dentistry Health Sciences University O

• Arisue Makoto

  Department Of Orthopaedic Surgery Hokkaido University Graduate School Of Medicine

• Arisue Makoto

  Department Of Oral Maxillo-facial Surgery School Of Dentistry Health Sciences University Of Hokkaido

• Murata Masaru

  2nd Department Of Oral Surgery School Of Dentistry Health Sciences University Of Hokkaido

• Murata Masaru

  Department Of Oral And Maxillofacial Surgery School Of Dentistry Health Sciences University Of Hokka

• Nagai Noriyuki

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Murata Masaru

  Department Of Oral And Maxillofacial Surgery School Of Dentistry Health Sciences University Of Hokka

• Sato Daisuke

  Second Department Of Oral Surgery School Of Dentistry Health Sciences University Of Hokkaido

• Kuboki Yoshinori

  Department Of Biochemistry Hokkaido University Dental School

• Kuboki Yoshinori

  Department Of Oral Biochemistry School Of Dentistry Hokkaido University

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