Geometry of artificial ECM Three-Dimensional Structure of Titanium-Web (TW) Promotes Differentiation of Human Bone Marrow Mesenchymal Cells into Osteoblasts(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
- 論文の詳細を見る
We demonstrate that a new culture system using a titanium web (TW) consisted of titanium fibers (50mm diameter) can promote differentiation of mesenchymal cells into osteoblasts without conventional application of dexamethasone. Human mesenchymal stem cells (hMSC, Cambrex) and MC3T3-E1 were cultured on titanium web (87% of porosity). ALP/DNA in hMSC at 2 weeks was 2 times higher and MC3T3-E1 at 4 weeks was 4 times higher on TW than those on the conventional plastic dishes. Effect of 3D structure of TW is self-evident and the results will open a new age of 3D bone cell biology using TW.
- 硬組織再生生物学会の論文
著者
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Kokai Yasuo
School Of Medicine Sapporo Medical University
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Katoh Hideki
School Of Dentistry Health Sciences University Of Hokkaido
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Kaku Tohru
Department Of Oral Pathology Hokkaido Health Sciences University Of Hokkaido
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Kaku Tohru
School Of Dentistry Health Sciences University Of Hokkaido
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Kuboki Y
Hokkaido University
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Li Dong
School of Medicine, Sapporo Medical University
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Iku Shouhei
Koken Bioscience Institute
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Nemoto Kazuki
Koken Bioscience Institute
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Odajima Tetsuya
School of Medicine, Sapporo Medical University
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Yoshimoto Ryota
School of Dentistry, Health Sciences University of Hokkaido
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Shiota Hiroyuki
Medical Device Group, Nippon Cable System Inc.
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Seki Yasuo
Medical Device Group, Nippon Cable System Inc.
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Ogura Naomi
Nihon University School of Dentistry at Matsudo
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Abiko Yoshimitsu
Nihon University School of Dentistry at Matsudo
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Kuboki Yoshinori
School of Medicine, Sapporo Medical University
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Seki Yasuo
Medical Device Department Hi-lex Corporation
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Yoshimoto Ryota
Second Department of Oral Maxillofacial Surgery, University of Hokkaido
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Shiota Hiroyuki
Medical Device Department Hi-lex Corporation
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Yoshimoto Ryota
Second Department Of Oral Maxillofacial Surgery University Of Hokkaido
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Odajima Tetsuya
School Of Medicine Sapporo Medical University
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Li Dong
School Of Medicine Sapporo Medical University
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Li Dong
School of Energy Science and Engineering, Harbin Institute of Technology, Harbin 150001, China
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