mRNA Expression of MT1-MMP, MMP-9,Cathepsin K, and TRAP in Highly Enriched Osteoclasts Cultured on Several Matrix Proteins and Ivory Surfaces

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概要

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• We demonstrated that the transcriptional expression of MT1-MMP, MMP-9,cathepsin K, and TRAP in highly enriched osteoclasts were regulated by different matrix proteins that bind to integrin on osteoclast, such as collagen type I (CoI), fibronectin (FN), vitronectin (VN), osteopontin (OPN), and ivory. Results suggested that the OPN-integrin α_vβ_3 binding plays a more important role than CoI-α_2β_1 binding in the regulation of osteoclast activity.

• 社団法人日本農芸化学会の論文
• 2000-08-23

著者

• KUBOKI Yoshinori

  Department of Oral Biochemistry, School of Dentistry, Hokkaido University

• Uemura Toshimasa

  National Chemical Laboratory For Industry (tsukuba Research Center)

• Uemura Toshimasa

  National Institute For Advanced Interdisciplinary Research (nair) Tsukuba Research Center:crest Jst

• Liu Yinkun

  Liver Cancer Institute Affiliated Zhongshan Hospital Of Fudan University

• Kuboki Yoshinori

  Department Of Biochemistry Hokkaido University School Of Dentistry

• Kuboki Y

  Hokkaido Univ. Hokkaido Jpn

• Koyano Yasuhiko

  Department Of Orthopaedic Surgery Jikei University School Of Medicine

• Kuboki Yoshinori

  Department Of Biochemistry Hokkaido University Dental School

• Liu Yin-kun

  Liver Cancer Institute, Shanghai Medical University

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