Effect of Rhubarb on Heat Shock Protein 70 Expression in Lung Tissues from Rats with Acute Lung Injury Induced by Lipopolysaccharide
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the expression of HSP70 in acute lung injury (ALI) induced by endotoxin (lipopolysaccharide: LPS) and the protective mechanisms of rhubarb against ALI. LPS was injected into rats via the internal jugular vein to induce ALI and rhubarb extract was given by intraperitoneal injection. The rats were divided into 4 groups: saline control group; LPS-induced ALI group; ALI treated with prophylactic rhubarb group; and ALI treated with therapeutic rhubarb group. The rats were sacrificed 2 hours after injection of LPS or saline. Physiological and pathological examinations were conducted, including arterial gas analysis, lung coefficient, hematoxylin-eosin staining, and HSP70 expression (immunohistochemistry and Western blotting). In the LPS-induced ALI group, interstitial edema, neutrophil infiltration, plasma exudation in alveoli, and damaged vascular endothelium were observed. HSP70 levels were slightly increased in LPS-treated rats, while HSP70 expression was enhanced significantly and overall lung function was improved in rhubarb-treated groups compared to ALI model rats. These data confirm that rhubarb protects rats from LPS-induced ALI and upergulates HSP70 expression. Thus, the protective effect of rhubarb may be mediated by the HSP70 signaling pathway.
- 硬組織再生生物学会の論文
著者
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Tamamura Ryo
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Setsu Kojun
Laboratories for Structure and Function Research, Faculty of Pharmaceutical science, Tokushima Bunri
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Inoue Masahisa
Laboratories for Structure and Function Research, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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Inoue Masahisa
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Inoue Masahisa
徳島文理大学 薬学部機能形態学
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Setsu K
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Setsu Kojun
Laboratory For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri Un
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Setsu Kojun
Laboratories For Structure And Function Reaearch Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Inoue Masahisa
Laboratory For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri Un
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Xin Jin
China Medical University
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Jin Kang
Department Of Emergency Medicine The First Hospital China Medical University
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Kan Rui
Department of Virology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama
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Tamamura Ryo
Department Of Oral Pathology And Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Tamamura Ryo
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Tamamura Ryo
Deparment Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical Sc
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Rui Kan
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Kan Rui
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Tian You
Department of Emergency Medicine, The First Hospital, China Medical University
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Tian You
Department Of Emergency Medicine The First Hospital China Medical University
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Inoue Masahisa
Department Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry A
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Setsu Kojun
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Tamamura Ryo
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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