Intestinal Absorption of Lysozyme Molecules and their Destination, an Immunohistochemical Study on Rat

概要

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Egg white lysozyme is now used clinically for the therapy of inflammatory diseases of respiratory tracts by oral administration. No definite evidence, however, has been presented to show directly the intestinal absorption of lysozyme molecules keeping the enzymatic activity in situ. We therefore tried to immunohistochemically detect egg white lysozyme on the tissues of the intestines and other organs of rats taken out at varied time intervals after the oral administration of the lysozyme. Observations of these rat tissues revealled the egg white lysozyme on the surface of intestinal epithelial cells and in the core tissues of villi, liver parenchymal cells and renal tubular cells showing the specific reaction to the antibody. The findings indicate that egg white lysozyme molecules can be absorbed through the healthy intestinal mucosa of rat keeping the antigenic specificity without being decomposed into amino acids.
日本組織細胞化学会の論文