Studies on the Intestinal Absorption of Pollen Proteins, Observations on Rat

概要

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As one of the inlets to the mechanism of oral immunotolerance induced by pollen powder, the absorption of antigenic pollen proteins (PPs) through the healthy intestinalmucosa and their destinations were observed. Immunohistochemical observations of the organs of rats given PPs into the digestive tract revealed that PPs were adhered to the surface of the mucous epithelial cells of jejunum being taken into the cells by pinocytosis and then transferred to the blood capillaries, indicating that the antigenic PPs are absorbed through the normal intestinal epithelium keeping the antigenicity. One hour after the PPs administration the absorbed proteins were found in liver parenchymal cells and kidney convoluted tubules but not in spleen and lymphatic tissues. Three hours after administration the distinct positive reaction of PPs disappeared leaving only faint reaction in some liver parenchymal cells. The findings indicate that intestinal epithelial cells, liver parenchymal cells and or renal tubular cells will be closely related to the development of oral immunotolerance.
日本組織細胞化学会の論文