Fine Deletional Mapping of Chromosome 4q22-35 Region in Oral Cancer(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

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概要

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• We analyzed loss of heterozygosity in detail of the long arm of chromosome 4 in 40 oral cancer by using 16 microsatellite markers based on the recent data from human genome sequence and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers D4S2623 and D4S1644 with an allelic deletion of 44% and 39%, respectively. Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5Mbp around the marker, D4S2623. Caspase 6 is just localized 280kb distant from the marker, D4S2623. Fine mapping of this region with possible tumor suppressor gene suggest caspase 6 as a putative tumor suppressor gene. Further molecular analysis of caspase 6 should be performed to clarify its role in oral carcinogenesis.

• 硬組織再生生物学会の論文

著者

• Nagai Noriyuki

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Lim Ji-jun

  Department Of Oral Pathology Seoul National University

• Shinnou Yasuo

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi

• Shinno Yasuo

  Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences

• Shimizu Kenji

  Department Of Molecular Genetics Graduate School Of Medicine Dentistry And Pharmaceutical Sciences O

• Gunduz Mehmet

  Department Of Otolaryngology Head And Neck Surgery Wakayama Medical University

• Gunduz Mehmet

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Shimizu Kenji

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Esra Gunduz

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Gunduz Esra

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Yoshiyama Masahiro

  Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences

• Nagai Noriyuki

  Department Of Oral Pathology Okayama University Dental School

• Gunduz Esra

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Jia Li-qun

  China-Japan Friendship Hospital

• Imura Masayuki

  Japan Institute for Advanced Dentistry

• Nagai Noriyuki

  Dept. Of Oral Pathology Okayama Univ. Dental School.

• Gunduz Mehmet

  岡山大学大学院医歯学総合研究科病態機構学講座:口腔病理病態学分野

• Gunduz Esra

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi

• Nagai Noriyuki

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Nagai Noriyuki

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

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