Genome-wide Loss of Heterozygosity Analysis in Head and Neck Squamous Cell Carcinomas(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
- 論文の詳細を見る
Identifying the tumor suppressor gene (TSG) loci by genomic studies is an important step to uncover the molecular mechanisms involved in HNSCC pathogenesis. We therefore performed comprehensive analyses on loss of heterozygosity (LOH) using a genome-wide panel of 191 microsatellite markers in 22 HNSCC samples. We found 53 markers with significantly high LOH (>30%) on 21 chromosomal arms, the highest values of those were observed on 3p, 9p, 13q, 15q, and 17p, corresponding to D3S2432 (67%), D9S921-D9S925 (67%) and GATA62F03 (86%), D13S1493 (60%), D15S211 (62%) and D17S1353 (88%), respectively. Fifteen hot spots of LOH were defined in 13 chromosomal arms reported previously in HNSCCs. Furthermore, we identified 5 novel hot spots of LOH on 3 chromosomal arms in HNSCC at 2q33 (D2S1384), 2q37 (D2S125), 8q12-13 (D8S1136), 8q24 (D8S1128) and 15q21 (D15S211). In conclusion, our comprehensive allelotype analyses have unveiled and confirmed a total of 20 possible TSG loci that could be involved in the development of HNSCC. These results provide useful clues for identification of putative TSGs involved in HNSCC by fine mapping of the suspected regions.
- 硬組織再生生物学会の論文
著者
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Nagai Noriyuki
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Hiura Yumiko
Japan Institute For Advanced Dentistry
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Shimizu Kenji
Department Of Molecular Genetics Graduate School Of Medicine Dentistry And Pharmaceutical Sciences O
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BEDER Levent
Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University
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Beder Levent
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Gunduz Mehmet
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Fukunishi Keihachi
Japan Institute for Advanced Dentistry
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Nishizaki Kazunori
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Shimizu Kenji
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Matsumoto Noriaki
Japan Institute for Advanced Dentistry
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Beder Levent
Department Of Otolaryngology Head And Neck Surgery Wakayama Medical University
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Nishizaki Kazunori
Department Of Otolaryngology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okaya
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Nishizaki Kazunori
Department Of Otolaryngology-head And Neck Surgery Graduate School Of Medicine And Dentistry
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Nishizaki Kazunori
Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Fukushima Kunihiro
Department Of Otolaryngology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okaya
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Nishizaki Kazunori
Department Of Human Morphology Okayama University Graduate School Of Medicine Dentistry And Pharmace
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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