Identification of the Genomic Structure of Tumor Suppressor ING1 and Mutation Analysis in Head and Neck Squamous Cell Carcinomas(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
- 論文の詳細を見る
A candidate tumor suppressor gene, ING1 has been recently cloned and mapped to 13q33-34 region. We characterized the genomic structure of the human ING1 gene and detected somatic mutations of the ING1 gene in head and neck squamous cell carcinomas. 23 out of 34 informative cases (68%) of tumors showed loss of heterozygosity at chromosome 13q33-34, where the ING1 gene is located. By sequence analysis three exons and 2 introns of ING1 were identified. Mutation analysis of ING1 gene showed three missense and three silent changes.
- 硬組織再生生物学会の論文
著者
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Nagai Noriyuki
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Lim Ji-jun
Department Of Oral Pathology Seoul National University
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Shimizu Kenji
Department Of Molecular Genetics Graduate School Of Medicine Dentistry And Pharmaceutical Sciences O
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Gunduz Mehmet
Department Of Otolaryngology Head And Neck Surgery Wakayama Medical University
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Esra Gunduz
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Gunduz Esra
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Nagai Noriyuki
Department Of Oral Pathology Okayama University Dental School
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Nagai Noriyuki
Graduate School Of Medicine Dentistry And Pharmacentical Sciences Okayama University
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Gunduz Mehmet
Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
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Gunduz Esra
Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
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Min Byung-Moo
Department of Oral Pathology, Seoul National University
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Lee Gene
Department of Oral Pathology, Seoul National University
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Shimizu Kenji
Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
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Katayama Takeyuki
Institute for Advanced Dentistry
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Min Byung-moo
Department Of Oral Pathology Seoul National University
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Nagai Noriyuki
Dept. Of Oral Pathology Okayama Univ. Dental School.
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Lee Gene
Department Of Oral Pathology Seoul National University
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Gunduz Mehmet
岡山大学大学院医歯学総合研究科病態機構学講座:口腔病理病態学分野
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Gunduz Esra
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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SHIMIZU Kenji
Graduate School of Engineering, Utsunomiya University
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