Functions of the Tumor Suppressor ING Family Genes in Head and Neck Cancer and Their Future Applications in Cancer Gene Therapy(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
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ING1 gene, the founding member of the ING tumor suppressor family, was originally identified through subtractive hybridization between normal mammary epithelial cells and breast cancer cell lines, and subsequent in vivo selection of genetic suppressor element that displayed oncogenic features. The four additional members of the ING family (ING2-5) were recently identified and all the gene products contain a highly conserved plant homeodomain (PHD) finger motif in the carboxy (C)-terminal end. Although exact functions of ING family genes have not been clarified, the gene products are involved in transcriptional regulation, apoptosis, cell cyle, angiogenesis and DNA repair through p53-dependent and -independent pathways and constituting complexes with histone acetyltransferases (HAT) and histone deacetylases (HDAC).
- 硬組織再生生物学会の論文
著者
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GUNDUZ Esra
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical
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Gunduz Esra
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Gunduz Esra
Department Of Medical Genetics Faculty Of Medicine Fatih University
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Gunduz Esra
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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