Deletional Mapping of 2q21-37 Region in Oral Cancer(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
スポンサーリンク
概要
- 論文の詳細を見る
Tumor suppressor genes are defined as genetic elements whose loss or mutational inactivation allows cells to display one or more phenotypes of neoplastic growth. Frequent deletion in a chromosomal region suggests existence of a candidate tumor suppressor gene. We analyzed Ch2q21-37.3 region by using 17 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues. Loss of heterozygosity (LOH) was detected at least one location in 36 of 39 (92%) tumor tissues. High deletions were detected at microsatellite marker locations, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S164 (29%), D2S125 (71%) and D2S140 (39%). Three frequently deleted regions at 2q22, 2q35-36 and 2q37.3 were observed. Chromosomal 2q22-37.3 region is highly populated with genes. Several candidate tumor suppressor genes in this region including such as ING5, CASP8, CASP10, PPP1R7 and BOK are located. We are currently analyzing inactivation mutations and mRNA expressions in oral squaomus cell carcinomas.
- 硬組織再生生物学会の論文
著者
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Nagai Noriyuki
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Shimizu Kenji
Department Of Molecular Genetics Graduate School Of Medicine Dentistry And Pharmaceutical Sciences O
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Gunduz Mehmet
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Shimizu Kenji
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Esra Gunduz
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Gunduz Esra
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Ouchida Mamoru
Department Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry A
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Gunduz Esra
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Cengiz Beyhan
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department o
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Ouchida Mamoru
Japan Institute for Advanced Dentistry
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Inoue Tomio
Japan Institute for Advanced Dentistry
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Cengiz Beyhan
Department Of Oral Pathology And Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Cengiz Beyhan
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Gunduz Esra
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Okauchi Mika
Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Okauchi Miho
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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