Clonal Analysis of Bilateral, Recurrent, or Systemically Multifocal Ocular Adnexal Lymphoma
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study is to determine the same or different clonality between bilateral or recurrent lesions, or between or among ocular adnexal lesions and systemically multifocal lesions in 10 consecutive patients with ocular adnexal lymphoma : 8 had extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) and 2 had mantle cell lymphoma, observed from 1995 to 2008 at Okayama University Hospital. A discrete DNA fragment was generated by polymerase chain reaction amplification of the immunoglobulin heavy chain gene from all samples except for two samples of bilateral orbital mantle cell lymphoma lesions and one sample of the scalp skin MALT lymphoma lesion. The size of DNA fragments were the same between bilateral orbital or conjunctival lesions of 5 patients, between original and recurrent conjunctival lesions of one patient, between the orbital lesion and the oral cavity lesion in one patient, and among bilateral orbital lesions, buccal, rectum, and stomach lesions of one patient. Sequencing of the DNA fragments showed the same sequence between bilateral or recurrent or multifocal lesions in 8 patients except for one : the bilateral orbital lesions, rectum, and stomach lesions shared the same sequence while the buccal lesion had one nucleotide difference compared to the sequence shared by the other 4 lesions. In conclusion, bilateral, recurrent, or systemically multifocal lesions of ocular adnexal lymphoma shared the clonality between or among the lesions. [J Clin Exp Hematopathol 50(1) : 27-38, 2010]
- 2010-05-01
著者
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YOSHINO Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutica
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MATSUO Toshihiko
Department of Ophthalmology, Okayama University Medical School and Graduate School of Medicine, Dent
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ICHIMURA Kouichi
Department of Pathology, Okayama University Medical School and Graduate School of Medicine, Dentistr
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OKADA Hiroyuki
Department of Gastroenterology/Hepatology, Okayama University Medical School and Graduate School of
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SHINAGAWA Katsuji
Department of Hematology/Oncology, Okayama University Medical School and Graduate School of Medicine
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FUKUSHIMA Kunihiro
Department of Otolaryngology/Head & Neck Surgery, Okayama University Medical School and Graduate Sch
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OKANO Mitsuhiro
Department of Otolaryngology/Head & Neck Surgery, Okayama University Medical School and Graduate Sch
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OTSUKA Masaki
Department of Dermatology, Okayama University Medical School and Graduate School of Medicine, Dentis
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Matsuo Toshihiko
Department Of Radiology Osaka City University Graduate School Of Medicine
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Yokozawa Toshiya
豊橋市民病院 血液･腫瘍内科
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Yoshino T
Division Of Pathology Okayama University Hospital
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Yoshida Takashi
Department Of Pathology Okayama University
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Yoshino Tadashi
岡山大学 医歯薬学総合研究科血液･腫瘍･呼吸器･アレルギー内科
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Itoh K
Division Of Oncology And Hematology National Cancer Center Hospital East
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Okada Hiroyuki
Department Of Cardiology Musashino Red Cross Hospital
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Ichimura Koichi
Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine
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Ishizawa K
Department Of Rheumatology And Hematology
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Shinagawa Katsuji
Department Of Hematology/oncology Okayama University Medical School And Graduate School Of Medicine
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Morito Toshiaki
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Itoh Kuniaki
Division Of Oncology And Hematology National Cancer Center Hospital East
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Itoh Kuniaki
Hematology And Oncology Division National Cancer Center Hospital East
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Kawase Ichiro
大阪大学 医学系研究科機能診断科学
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Otsuka Masaki
Department Of Dermatology Okayama University Medical School And Graduate School Of Medicine Dentistr
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Otsuka Masaki
Department Of Bioregulatory Medicine Ehime University Graduate School Of Medicine
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Ichimura Koichi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
岡山大学 医歯薬学総合研究科眼科学分野
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Shinagawa Katsuji
Department Of Biopathological Science Okayama University Graduate School Of Medicine And Dentistry
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Ichimura Koichi
Department Of Pathology Okayama University Graduate School Of Medicine And Dentistry
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Okano Mitsuhiro
Department Of Otolaryngology/head & Neck Surgery Okayama University Medical School And Graduate
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Okano Mitsuhiro
Department Of Mechanical Engineering Kansai University
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Yoshida Takashi
Department Of Hematology Japanese Red Cross Nagoya First Hospital
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Ichimura Koichi
Department Of Pathology And Molecular Diagnostics Aichi Cancer Center
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Ichimura Kouichi
Department Of Pathology Okayama University Medical School And Graduate School Of Medicine Dentistry
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Ichimura Kouichi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Matsuo Toshihiko
Department Of Ophthalmology Okayama University Medical School And Graduate School Of Medicine Dentis
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Matsuo Toshihiko
Department Of Ophthalmology National Hospital Organization Matsumoto Hospital
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Fukushima Kunihiro
Department Of Otolaryngology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okaya
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Fukushima Kunihiro
Department Of Otolaryngology/head & Neck Surgery Okayama University Medical School And Graduate
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Tadashi Yoshino
Second Department Of Pathology Okayama University Medical School
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Yoshino Tadashi
Department Of Pathology Okayama University
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Yoshino Tadashi
Department Of Hematology Okayama Rosai Hospital
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Tamada Yasuhiko
Department Of Dermatology Aichi Medical University Hospital
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshida T
Tohoku Univ. Sendai Jpn
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
Department Of Pathology And Pathobiology Okayama University Graduate School Of Medicine And Dentistr
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Matsuo Toshihiko
Department Of Communications And Integrated Systems Tokyo Institute Of Technology
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Matsuo Toshihiko
Department Of Ophthalmology Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Okada Hiroyuki
Department Of Gastroenterology/hepatology Okayama University Medical School And Graduate School Of M
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Yoshino Tadashi
Department Of Cytopathology Ayabe City Hospital
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Fukushima Kunihiro
Department of Otolaryngology and Head & Neck surgery, Okayama University
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Yoshino Tadashi
Department of Chemical Engineering, Hiroshima University
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